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Capsid mutant-AAV serotype 2 variant (AAV2-Retro system) - Introduction

GeneMedi's AAV2-Retro (Retrograde) Vector System (AAV serotype 2 Retro (Retrograde) helper-free packaging plasmids system) is including AAV2-Retro (Retrograde) Rep-Cap plamid (AAV2-Retro (Retrograde)-RC plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).

You can choose your suiltable AAV expression vector plasmids from GeneMedi's AAV expression vector core. The AAV expression vector plasmids were constructed with differernt expression cassettes,containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference ). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.

AAV2-Retro (Retrograde) Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV2-Retro (Retrograde) capsid-engineered protein.

The tissue tropism of AAV2-Retro (Retrograde) vector has been validated in robust retrograde transport in the brain. The AAV2-Retro is a powerful tool for neuron signal tracing in the brain and in CNS instead of infective pseudorabies virus (PRV) or Canine adenovirus (CAV).