Products
Torapsel Biosimilar Fusion Protein (P-Selectin) for Research
Pre-Made Torapsel Biosimilar, Fusion Protein targeting SELP fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting CD62/CD62P/GMP140/GRMP/LECAM3/PADGEM/PSEL is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Torapsel is a 42-89-glycoprotein (human clone PMT21:PL85 P-selectin glycoprotein ligand 1) fused with immunoglobulin (human constant region). It has been used for the prevention of Ischemia Reperfusion Injury
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-1027-1mg | 1mg | 3090 |
| GMP-Bios-INN-1027-10mg | 10mg | |
| GMP-Bios-INN-1027-100mg | 100mg | |
| GMP-Bios-INN-1027-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Torapsel Biosimilar, Fusion Protein targeting SELP fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting CD62/CD62P/GMP140/GRMP/LECAM3/PADGEM/PSEL |
| INN Name | Torapsel |
| Target | SELP |
| Format | Fusion Protein |
| Derivation | human |
| Species Reactivity | human |
| CH1 Isotype | Fusion - [SELPLG (selectin P ligand, selectin P glycoprotein ligand, PSGL-1, CD162) 42-89]2 - IGHG1 Fc (Fragment constant) |
| VD LC | Fusion - [SELPLG (selectin P ligand, selectin P glycoprotein ligand, PSGL-1, CD162) 42-89]2 - IGHG1 Fc (Fragment constant) |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | Wyeth Pharmaceuticals (Madison NJ USA) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - SELP
1. Protein P-selectin
2. Gene SELP
3. Organism Homo sapiens (Human)
Function
Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
