Products
Vapaliximab Biosimilar Monoclonal Antibody (VAP-1) for Research
Anti-AOC3 therapeutic antibody (Pre-made Vapaliximab biosimilar, Whole mAb) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vapaliximab is a chimeric monoclonal antibody[1] and an experimental immunosuppressive drug.[citation needed] Development was discontinued by 212.[2]
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-1046-1mg | 1mg | 3090 |
| GMP-Bios-INN-1046-10mg | 10mg | |
| GMP-Bios-INN-1046-100mg | 100mg | |
| GMP-Bios-INN-1046-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Vapaliximab Biosimilar, Whole Mab, Anti-Aoc3 Antibody: Anti-HPAO/SSAO/VAP-1/VAP1 therapeutic antibody |
| INN Name | Vapaliximab |
| Target | AOC3 |
| Format | Whole mAb |
| Derivation | Chimeric |
| Species Reactivity | human |
| CH1 Isotype | IgG2 - kappa |
| VD LC | IgG2 - kappa |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | 0 |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - AOC3
1. Protein Membrane primary amine oxidase
2. Gene AOC3
3. Organism Homo sapiens (Human)
Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Catalytic activity
an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4+
EC:1.4.3.21
Source: Rhea.
Cofactor
Protein has several cofactor binding sites:
Cu cation
Note: Binds 1 copper ion per subunit.
Ca2+
Note: Binds 2 calcium ions per subunit.
L-topaquinone
Note: Contains 1 topaquinone per subunit.
Kinetics
KM=1.94 mM for 2-phenylethylamine
KM=0.67 mM for methylamine
