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The world is in midst of the COVID-19 pandemic. Recently A new "double mutant" variant of the coronavirus has been detected from samples collected in India. The two mutations (E484Q and L452R mutations) come together in the same virus, may be more infectious or less affected by vaccines.1

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) double mutant variant B.1.617 lineage, S:E484Q+L452R (India)


SARS-COV-2 (2019nCOV) -double mutant variant B.1.617 lineage, S:E484Q+L452R (India) of Spike protein & ACE2 competition binding assay for efficacy evaluation of COVID-19 vaccines and therapeutic antibodies

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) -double mutant variant B.1.617 lineage, S:E484Q+L452R (India)

Mutations of Spike protein in SARS-COV-2 (2019nCOV) double mutant variant B.1.617 lineage, S:E484Q+L452R (India)

Two of the spike mutations are at key residues in the RBD (E484Q and L452R), two are in the N-terminal domain (T95I and E154K).2.

Spike Mutation in SARS-COV-2 (2019nCOV) double mutant variant B.1.617 lineage, S:E484Q+L452R (India) Spike-S1 Subunit
N Terminal
T95I
E154K Important residues mutation
Spike-RBD L452R Important residues mutation
E484Q Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit P681R

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Figure. Amino acid changes in the spike region of the double mutant variant B.1.617 lineage, S:E484Q+L452R (India) genomes2

Reference

1.Soutik Biswas. 'Double mutant': What are the risks of India's new Covid-19 variant. https://www.bbc.com/news/world-asia-india-56517495.
2.INSACOG. “Genome Sequencing by INSACOG shows variants of concern and a Novel variant in India ” INSACOG, 2021. https://pib.gov.in/PressReleaseIframePage.aspx?PRID=1707177.




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