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The world is in midst of the COVID-19 pandemic. Recently a new SARS-CoV-2 (2019nCOV)lineage (B.1.526) emerged in New York and spread rapidly. The New York variant B.1.526 lineage is characterised by six lineage-defining mutations in the spike protein, including D614G mutation and one at important residues in the receptor-binding domain (S477N or E484K)1.The combination of E484K or S477N with a D253G mutation of the B.1.526 lineage that might confer immune escape and the increased number of COVID-19 cases2. The position S477 is shown be S477N or S477G.

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) New York variant B.1.526 lineage


SARS-COV-2 (2019nCOV) -New York variant B.1.526 lineage of Spike protein & ACE2 competition binding assay for efficacy evaluation of COVID-19 vaccines and therapeutic antibodies

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) -New York variant B.1.526 lineage

Mutations of Spike protein in SARS-COV-2 (2019nCOV) B.1.526 lineage spread in New York

One spike mutation is at key residues in the RBD (S477N or E484K), two are in the N-terminal domain (T95I and D253G) and one is in loop 2 (A701V) 1. The position S477 is shown be S477N or S477G.

Spike Mutation in SARS-COV-2 (2019nCOV) B.1.526 lineage
SP L5F
Spike-S1 Subunit
N Terminal
T95I
D253G Important residues mutation
Spike-RBD S477N/G or E484K Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit A701V

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Figure. Amino acid changes in the spike region of the B.1.526 genomes1

Reference

1.William A. Haseltine. New York Finds Its Own Covid Variants. The News Is Not Good. https://www.forbes.com/sites/williamhaseltine/2021/02/26/new-york-finds-its-own-covid-variants-the-news-is-not-good/?sh=4b0a20376de7.
2.Erica Lasek-Nesselquist, Pascal Lapierre, Erasmus Schneider, Kirsten St. George, View ORCID ProfileJanice Pata. The localized rise of a B.1.526 SARS-CoV-2 variant containing an E484K mutation in New York State. doi: https://doi.org/10.1101/2021.02.26.21251868.




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