Human IL7/IL-7 ORF/cDNA clone-Lentivirus plasmid (NM_000880)

Cat. No.: pGMLP-IL-010
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human IL7/IL-7 Lentiviral expression plasmid for IL7 lentivirus packaging, IL7 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP-IL-010
Gene Name IL7
Accession Number NM_000880
Gene ID 3574
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 534 bp
Gene Alias IL-7
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGTTCCATGTTTCTTTTAGGTATATCTTTGGACTTCCTCCCCTGATCCTTGTTCTGTTGCCAGTAGCATCATCTGATTGTGATATTGAAGGTAAAGATGGCAAACAATATGAGAGTGTTCTAATGGTCAGCATCGATCAATTATTGGACAGCATGAAAGAAATTGGTAGCAATTGCCTGAATAATGAATTTAACTTTTTTAAAAGACATATCTGTGATGCTAATAAGGAAGGTATGTTTTTATTCCGTGCTGCTCGCAAGTTGAGGCAATTTCTTAAAATGAATAGCACTGGTGATTTTGATCTCCACTTATTAAAAGTTTCAGAAGGCACAACAATACTGTTGAACTGCACTGGCCAGGTTAAAGGAAGAAAACCAGCTGCCCTGGGTGAAGCCCAACCAACAAAGAGTTTGGAAGAAAATAAATCTTTAAAGGAACAGAAAAAACTGAATGACTTGTGTTTCCTAAAGAGACTATTACAAGAGATAAAAACTTGTTGGAATAAAATTTTGATGGGCACTAAAGAACACTGA
ORF Protein Sequence MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T35232-Ab Anti-IL7/ IL-7 functional antibody
    Target Antigen GM-Tg-g-T35232-Ag IL7 protein
    ORF Viral Vector pGMLP000532 Human IL7 Lentivirus plasmid
    ORF Viral Vector pGMLV001094 Human IL7 Lentivirus plasmid
    ORF Viral Vector pGMAP000249 Human IL7 Adenovirus plasmid
    ORF Viral Vector pGMLP-IL-010 Human IL7 Lentivirus plasmid
    ORF Viral Vector pGMAP-IL-093 Human IL7 Adenovirus plasmid
    ORF Viral Vector vGMLP000532 Human IL7 Lentivirus particle
    ORF Viral Vector vGMLV001094 Human IL7 Lentivirus particle
    ORF Viral Vector vGMAP000249 Human IL7 Adenovirus particle
    ORF Viral Vector vGMLP-IL-010 Human IL7 Lentivirus particle
    ORF Viral Vector vGMAP-IL-093 Human IL7 Adenovirus particle


    Target information

    Target ID GM-T35232
    Target Name IL7
    Gene ID 3574, 16196, 574168, 25647, 101084597, 751768, 280827, 100059131
    Gene Symbol and Synonyms A630026I06Rik,hlb368,IL-7,IL7
    Uniprot Accession P13232
    Uniprot Entry Name IL7_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease ovarian cancer, Overactive bladder
    Gene Ensembl ENSG00000104432
    Target Classification Not Available

    The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]



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