Human ANG/ALS9/HEL168 ORF/cDNA clone-Lentivirus plasmid (NM_001145)

Cat. No.: pGMLP000061
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human ANG/ALS9/HEL168 Lentiviral expression plasmid for ANG lentivirus packaging, ANG lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product Description

Catalog ID pGMLP000061
Gene Name ANG
Accession Number NM_001145
Gene ID 283
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 444 bp
Gene Alias ALS9,HEL168,RAA1,RNASE4,RNASE5
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGTGATGGGCCTGGGCGTTTTGTTGTTGGTCTTCGTGCTGGGTCTGGGTCTGACCCCACCGACCCTGGCTCAGGATAACTCCAGGTACACACACTTCCTGACCCAGCACTATGATGCCAAACCACAGGGCCGGGATGACAGATACTGTGAAAGCATCATGAGGAGACGGGGCCTGACCTCACCCTGCAAAGACATCAACACATTTATTCATGGCAACAAGCGCAGCATCAAGGCCATCTGTGAAAACAAGAATGGAAACCCTCACAGAGAAAACCTAAGAATAAGCAAGTCTTCTTTCCAGGTCACCACTTGCAAGCTACATGGAGGTTCCCCCTGGCCTCCATGCCAGTACCGAGCCACAGCGGGGTTCAGAAACGTTGTTGTTGCTTGTGAAAATGGCTTACCTGTCCACTTGGATCAGTCAATTTTCCGTCGTCCGTAA
ORF Protein Sequence MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T54229-Ab Anti-ANGI/ ANG/ ALS9 functional antibody
    Target Antigen GM-Tg-g-T54229-Ag ANG protein
    ORF Viral Vector pGMLP000061 Human ANG Lentivirus plasmid
    ORF Viral Vector pGMLP001909 Human ANG Lentivirus plasmid
    ORF Viral Vector vGMLP000061 Human ANG Lentivirus particle
    ORF Viral Vector vGMLP001909 Human ANG Lentivirus particle


    Target information

    Target ID GM-T54229
    Target Name ANG
    Gene ID 283, 11727, 305843, 101082240, 100034041
    Gene Symbol and Synonyms ALS9,ANG,Ang1,HEL168,RAA1,RAB1,RNASE4,RNASE5,Rnase5a
    Uniprot Accession P03950
    Uniprot Entry Name ANGI_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Lung Cancer, Malignant neoplasm of bladder, Dent disease
    Gene Ensembl ENSG00000214274
    Target Classification Not Available

    The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]



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