Human ABCD2/ABC39/ALDL1 ORF/cDNA clone-Lentivirus plasmid (NM_005164)

Cat. No.: pGMLP001442
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human ABCD2/ABC39/ALDL1 Lentiviral expression plasmid for ABCD2 lentivirus packaging, ABCD2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP001442
Gene Name ABCD2
Accession Number NM_005164
Gene ID 225
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 2223 bp
Gene Alias ABC39,ALDL1,ALDR,ALDRP,hALDR
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGACACATATGCTAAATGCAGCAGCTGATCGAGTGAAATGGACCAGATCGAGTGCTGCTAAGAGGGCTGCCTGCCTGGTGGCTGCGGCATATGCTCTGAAAACCCTCTATCCCATCATTGGCAAGCGTTTAAAGCAATCTGGCCACGGGAAGAAAAAAGCAGCAGCTTACCCTGCTGCAGAGAACACAGAAATACTGCATTGCACCGAGACCATTTGTGAAAAACCTTCGCCTGGAGTGAATGCAGATTTCTTCAAACAGCTACTAGAACTTCGGAAAATTTTGTTTCCAAAACTTGTGACCACTGAAACAGGGTGGCTCTGCCTGCACTCAGTGGCTCTAATCTCAAGAACCTTTCTTTCTATCTATGTGGCTGGTCTGGATGGAAAAATCGTGAAAAGCATTGTGGAAAAGAAGCCTCGGACTTTCATCATCAAATTAATCAAGTGGCTTATGATTGCCATCCCTGCTACCTTCGTCAACAGTGCAATAAGGTACCTGGAATGCAAATTGGCTTTGGCCTTCAGAACTCGCCTAGTAGACCACGCCTATGAAACCTATTTTACAAATCAGACTTATTATAAAGTGATCAATATGGATGGGAGGCTGGCAAACCCTGACCAATCTCTTACGGAGGATATTATGATGTTCTCCCAATCTGTGGCTCACTTGTATTCCAATCTGACCAAACCTATTTTAGATGTAATGCTGACCTCCTATACACTCATTCAAACTGCTACATCCAGAGGAGCAAGCCCAATTGGGCCCACCCTACTAGCAGGACTTGTGGTGTATGCCACTGCTAAAGTGTTAAAAGCCTGTTCTCCCAAATTTGGCAAACTGGTGGCAGAGGAAGCACATAGAAAAGGCTATTTGCGGTATGTGCACTCGAGAATTATAGCCAATGTAGAAGAAATTGCCTTTTACAGAGGACATAAGGTAGAAATGAAACAACTTCAGAAAAGTTACAAAGCTTTAGCAGATCAGATGAACCTCATTTTATCCAAACGTTTGTGGTACATCATGATAGAACAGTTCCTGATGAAGTATGTTTGGAGCAGCAGTGGACTAATTATGGTGGCTATACCTATTATCACTGCAACTGGCTTTGCAGATGGTGAGGATGGCCAAAAGCAAGTTATGGTTAGTGAACGGACAGAAGCCTTTACCACTGCTCGAAATTTACTGGCCTCTGGAGCTGATGCTATTGAAAGGATTATGTCTTCATACAAAGAGGTCACTGAATTAGCAGGCTACACTGCTCGAGTGTACAATATGTTTTGGGTCTTTGATGAAGTAAAAAGAGGCATTTATAAGAGAACTGCTGTCATTCAAGAATCTGAAAGCCATAGCAAGAATGGAGCTAAGGTAGAATTACCTCTCAGTGACACATTGGCAATTAAAGGAAAAGTTATTGATGTGGATCACGGAATTATTTGTGAAAATGTTCCCATAATTACACCAGCAGGAGAAGTGGTGGCTTCCAGGCTAAACTTCAAAGTAGAAGAAGGAATGCATCTTTTGATAACTGGTCCCAATGGTTGTGGGAAAAGTTCTCTCTTCAGAATTCTAAGTGGGCTCTGGCCTGTGTATGAAGGAGTCCTCTATAAACCACCTCCTCAACATATGTTTTATATTCCACAAAGGCCATATATGTCTCTTGGAAGTCTTCGGGATCAAGTCATTTACCCTGATTCAGTGGATGATATGCATGATAAAGGTTATACAGACCAAGATCTGGAACGTATCCTACACAATGTCCATCTCTATCACATAGTTCAAAGAGAAGGAGGATGGGATGCTGTTATGGACTGGAAAGATGTCCTGTCAGGAGGGGAAAAGCAAAGAATGGGCATGGCTCGTATGTTTTATCATAAACCAAAATATGCCTTGCTGGATGAATGTACCAGTGCTGTCAGCATTGATGTCGAAGGAAAGATATTTCAGGCTGCAAAAGGGGCTGGAATTTCCTTACTGTCTATAACACACAGACCTTCTCTTTGGAAATACCACACACATTTATTACAGTTTGATGGTGAAGGAGGTTGGCGCTTTGAACAATTGGATACTGCTATCCGTTTGACATTGAGTGAAGAAAAACAAAAGCTAGAATCTCAGCTAGCTGGAATTCCCAAAATGCAGCAGAGACTCAATGAACTATGTAAAATTTTGGGAGAAGACTCAGTGCTGAAAACAATTAAAAATGAAGATGAGACATCTTAA
ORF Protein Sequence MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIKNEDETS

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP0282-Ab Anti-ABCD2 monoclonal antibody
    Target Antigen GM-Tg-g-IP0282-Ag ABCD2 protein
    ORF Viral Vector pGMLP001442 Human ABCD2 Lentivirus plasmid
    ORF Viral Vector vGMLP001442 Human ABCD2 Lentivirus particle


    Target information

    Target ID GM-IP0282
    Target Name ABCD2
    Gene ID 225, 26874, 697556, 84356, 101095424, 477643, 526436
    Gene Symbol and Synonyms ABC39,ABCD2,ALDL1,ALDR,ALDRP,hALDR
    Uniprot Accession Q9UBJ2
    Uniprot Entry Name ABCD2_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000173208
    Target Classification Not Available

    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]



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