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Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Package Catalog No. Price(In USD) Qty (Quantity) Sum(In USD)
5ug GMV-V-2019nCoV-102 1890
Shipping Cost: 130.00
Total:



Description

2019 nCoV related GeneSpike(S1+S2)-S1 HV 69-70 Deletion mutation(ΔH69/ΔV70, B.1.1.7 lineage)
Species HostSARS-COV-2 B.1.1.7 lineage
VectorpcDNA3.1(+)
Reporternull
Antibiotic in Mammalian cellNeomycin / G418
PromoterCMV
TagNo tag
Coden Optimizedcoden optimized for mamamlian

SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

Background Reading:
Information and products collection of SARS-COV-2 (2019nCOV) UK B.1.1.7 lineage
Information and products collection of spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

The world is in midst of the COVID-19 pandemic caused by SARS-CoV-2 (2019nCoV) infection. The Spike protein (S-protein) of SARS-CoV-2 (2019nCoV) mediates receptor (ACE2) binding and cell entry and is the dominant target of the immune system. Most mutations and deletions of SARS-CoV-2 occur in the coronavirus spike protein.

A deletion H69/V70 in Spike was present in over 3,000 sequences worldwide (2.5% of the available data), and largely in Europe from where most of the sequences in GISAID are derived. The structural impact of the double deletion was predicted by homology modelling of the spike NTD possessing H69/V70 using SWISS-MODEL. The H69/V70 deletion was predicted to alter the conformation of a protruding loop comprising residues 69-76, with the loop being predicted to be predicted to be pulled in the NTD.

Recently a novel SARS-COV-2 (2019nCOV) lineage, the B.1.1.7 lineage, with serials of site mutation, shows stronger infection ability in the UK. In SARS-COV-2 B.1.1.7 lineage, most mutations and deletions occur in the coronavirus spike protein. These deletions also include SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70).

GeneMedi offers pre-made gene ORF mutation plasmids of SARS-CoV-2 (2019nCoV) Spike(S1+S2)-HV 69-70 Deletion mutation(ΔH69/ΔV70).

The pre-made gene ORF vector of Spike(S1+S2)-N501Y mutation is coden optimized for mamamlian and can be used for mamalian expression.

GeneMedi also provides pre-made the lentivirus, adenovirus and AAV vector for the gene ORF plasmids of 2019 nCoV (SARS2 coronavirus).

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)