2019 nCoV (SARS CoV2 coronavirus) Spike(S1+S2)-S1 HV 69-70 Deletion mutation(ΔH69/ΔV70,B.1.1.7 lineage) pcDNA3.1(+) vector
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|Package||Catalog No.||Price(In USD)||Qty (Quantity)||Sum(In USD)|
|2019 nCoV related Gene||Spike(S1+S2)-S1 HV 69-70 Deletion mutation(ΔH69/ΔV70, B.1.1.7 lineage)|
|Species Host||SARS-COV-2 B.1.1.7 lineage|
|Antibiotic in Mammalian cell||Neomycin / G418|
|Coden Optimized||coden optimized for mamamlian|
SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)
The world is in midst of the COVID-19 pandemic caused by SARS-CoV-2 (2019nCoV) infection. The Spike protein (S-protein) of SARS-CoV-2 (2019nCoV) mediates receptor (ACE2) binding and cell entry and is the dominant target of the immune system. Most mutations and deletions of SARS-CoV-2 occur in the coronavirus spike protein.
A deletion H69/V70 in Spike was present in over 3,000 sequences worldwide (2.5% of the available data), and largely in Europe from where most of the sequences in GISAID are derived. The structural impact of the double deletion was predicted by homology modelling of the spike NTD possessing H69/V70 using SWISS-MODEL. The H69/V70 deletion was predicted to alter the conformation of a protruding loop comprising residues 69-76, with the loop being predicted to be predicted to be pulled in the NTD.
Recently a novel SARS-COV-2 (2019nCOV) lineage, the B.1.1.7 lineage, with serials of site mutation, shows stronger infection ability in the UK. In SARS-COV-2 B.1.1.7 lineage, most mutations and deletions occur in the coronavirus spike protein. These deletions also include SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70).
The pre-made gene ORF vector of Spike(S1+S2)-N501Y mutation is coden optimized for mamamlian and can be used for mamalian expression.
GeneMedi also provides pre-made the lentivirus, adenovirus and AAV vector for the gene ORF plasmids of 2019 nCoV (SARS2 coronavirus).
GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)
GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)