Anti-INGR1/ IFNGR/ IFNGR1 monoclonal antibody
Anti-INGR1/ IFNGR/ IFNGR1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IO066-Ab-1/ GM-Tg-hg-IO066-Ab-2 | Anti-Human IFNGR/IFNGR1 monoclonal antibody | Human |
GM-Tg-rg-IO066-Ab-1/ GM-Tg-rg-IO066-Ab-2 | Anti-Rat IFNGR/IFNGR1 monoclonal antibody | Rat |
GM-Tg-mg-IO066-Ab-1/ GM-Tg-mg-IO066-Ab-2 | Anti-Mouse IFNGR/IFNGR1 monoclonal antibody | Mouse |
GM-Tg-cynog-IO066-Ab-1/ GM-Tg-cynog-IO066-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IFNGR/IFNGR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IO066-Ab-1/ GM-Tg-felg-IO066-Ab-2 | Anti-Feline IFNGR/IFNGR1 monoclonal antibody | Feline |
GM-Tg-cang-IO066-Ab-1/ GM-Tg-cang-IO066-Ab-2 | Anti-Canine IFNGR/IFNGR1 monoclonal antibody | Canine |
GM-Tg-bovg-IO066-Ab-1/ GM-Tg-bovg-IO066-Ab-2 | Anti-Bovine IFNGR/IFNGR1 monoclonal antibody | Bovine |
GM-Tg-equg-IO066-Ab-1/ GM-Tg-equg-IO066-Ab-2 | Anti-Equine IFNGR/IFNGR1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IO066-Ab-1/ GM-Tg-hg-IO066-Ab-2; GM-Tg-rg-IO066-Ab-1/ GM-Tg-rg-IO066-Ab-2; GM-Tg-mg-IO066-Ab-1/ GM-Tg-mg-IO066-Ab-2; GM-Tg-cynog-IO066-Ab-1/ GM-Tg-cynog-IO066-Ab-2; GM-Tg-felg-IO066-Ab-1/ GM-Tg-felg-IO066-Ab-2; GM-Tg-cang-IO066-Ab-1/ GM-Tg-cang-IO066-Ab-2; GM-Tg-bovg-IO066-Ab-1/ GM-Tg-bovg-IO066-Ab-2; GM-Tg-equg-IO066-Ab-1/ GM-Tg-equg-IO066-Ab-2 |
Products Name | Anti-IFNGR/IFNGR1 monoclonal antibody |
Format | mab |
Target Name | IFNGR |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-IFNGR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-874 | Pre-Made Interferon Gamma Biosimilar, Recombinant Protein targeting IFNGR1: Recombinant therapeutic protein targeting CD119/IFNGR/IMD27A/IMD27B |
Target Antigen | Products Developing | Multi-species INGR1/ IFNGR/ IFNGR1 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm001350 | mouse Ifngr1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001350 | mouse Ifngr1 Lentivirus particle |
Target information
Target ID | GM-IO066 |
Target Name | IFNGR |
Gene ID | 3459,15979,116465,100423877,100856077,101086811,508619,100073195 |
Gene Symbol and Synonyms | CD119,Ifgr,IFN-gammaR,IFNGR,IFNGR1,IFNR1,IMD27A,IMD27B,Nktar |
Uniprot Accession | P15260 |
Uniprot Entry Name | INGR1_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000027697 |
Target Classification | Checkpoint-Immuno Oncology |
The target: IFNGR, gene name: IFNGR1, also named as CD119, IFNGR, IMD27A, IMD27B. This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.