- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-TIM-3 monoclonal antibody
Pre-made anti-TIM-3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TIM-3/HAVCR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO140-Ab-1/ GM-Tg-hg-IO140-Ab-2 | Anti-Human TIM-3/HAVCR2 monoclonal antibody | Human |
| GM-Tg-rg-IO140-Ab-1/ GM-Tg-rg-IO140-Ab-2 | Anti-Rat TIM-3/HAVCR2 monoclonal antibody | Rat |
| GM-Tg-mg-IO140-Ab-1/ GM-Tg-mg-IO140-Ab-2 | Anti-Mouse TIM-3/HAVCR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IO140-Ab-1/ GM-Tg-cynog-IO140-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TIM-3/HAVCR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO140-Ab-1/ GM-Tg-felg-IO140-Ab-2 | Anti-Feline TIM-3/HAVCR2 monoclonal antibody | Feline |
| GM-Tg-cang-IO140-Ab-1/ GM-Tg-cang-IO140-Ab-2 | Anti-Canine TIM-3/HAVCR2 monoclonal antibody | Canine |
| GM-Tg-bovg-IO140-Ab-1/ GM-Tg-bovg-IO140-Ab-2 | Anti-Bovine TIM-3/HAVCR2 monoclonal antibody | Bovine |
| GM-Tg-equg-IO140-Ab-1/ GM-Tg-equg-IO140-Ab-2 | Anti-Equine TIM-3/HAVCR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO140-Ab-1/ GM-Tg-hg-IO140-Ab-2; GM-Tg-rg-IO140-Ab-1/ GM-Tg-rg-IO140-Ab-2; GM-Tg-mg-IO140-Ab-1/ GM-Tg-mg-IO140-Ab-2; GM-Tg-cynog-IO140-Ab-1/ GM-Tg-cynog-IO140-Ab-2; GM-Tg-felg-IO140-Ab-1/ GM-Tg-felg-IO140-Ab-2; GM-Tg-cang-IO140-Ab-1/ GM-Tg-cang-IO140-Ab-2; GM-Tg-bovg-IO140-Ab-1/ GM-Tg-bovg-IO140-Ab-2; GM-Tg-equg-IO140-Ab-1/ GM-Tg-equg-IO140-Ab-2 |
| Products Name | Anti-TIM-3/HAVCR2 monoclonal antibody |
| Format | mab |
| Target Name | TIM-3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TIM-3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IO140-Ag-1 | Recombinant multi-species HAVR2/ TIM-3/ HAVCR2 protein |
| ORF Viral Vector | pGMLP005033 | human HAVCR2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP005033 | human HAVCR2 Lentivirus particle |
| ORF Viral Vector | pGMLPm003483 | mouse Havcr2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003483 | mouse Havcr2 Lentivirus particle |
Target information
| Target ID | GM-IO140 |
| Target Name | TIM-3 |
| Gene ID | 84868,171285,363578,714891,479318,101089981,768047,100071246 |
| Gene Symbol and Synonyms | CD366,HAVcr-2,HAVCR2,KIM-3,SPTCL,Tim-3,TIM3,TIMD-3,TIMD3 |
| Uniprot Accession | Q8TDQ0,P0C0K5 |
| Uniprot Entry Name | HAVR2_HUMAN,HAVR2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135077 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TIM-3, gene name: HAVCR2, also named as CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3. The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
