Anti-HMGCR monoclonal antibody

Pre-made anti-HMGCR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HMGCR/HMGCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0005-Ab-1/ GM-Tg-hg-IP0005-Ab-2Anti-Human HMGCR monoclonal antibodyHuman
GM-Tg-rg-IP0005-Ab-1/ GM-Tg-rg-IP0005-Ab-2Anti-Rat HMGCR monoclonal antibodyRat
GM-Tg-mg-IP0005-Ab-1/ GM-Tg-mg-IP0005-Ab-2Anti-Mouse HMGCR monoclonal antibodyMouse
GM-Tg-cynog-IP0005-Ab-1/ GM-Tg-cynog-IP0005-Ab-2Anti-Cynomolgus/ Rhesus macaque HMGCR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0005-Ab-1/ GM-Tg-felg-IP0005-Ab-2Anti-Feline HMGCR monoclonal antibodyFeline
GM-Tg-cang-IP0005-Ab-1/ GM-Tg-cang-IP0005-Ab-2Anti-Canine HMGCR monoclonal antibodyCanine
GM-Tg-bovg-IP0005-Ab-1/ GM-Tg-bovg-IP0005-Ab-2Anti-Bovine HMGCR monoclonal antibodyBovine
GM-Tg-equg-IP0005-Ab-1/ GM-Tg-equg-IP0005-Ab-2Anti-Equine HMGCR monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-IP0005-Ab-1/ GM-Tg-hg-IP0005-Ab-2; GM-Tg-rg-IP0005-Ab-1/ GM-Tg-rg-IP0005-Ab-2;
GM-Tg-mg-IP0005-Ab-1/ GM-Tg-mg-IP0005-Ab-2; GM-Tg-cynog-IP0005-Ab-1/ GM-Tg-cynog-IP0005-Ab-2;
GM-Tg-felg-IP0005-Ab-1/ GM-Tg-felg-IP0005-Ab-2; GM-Tg-cang-IP0005-Ab-1/ GM-Tg-cang-IP0005-Ab-2;
GM-Tg-bovg-IP0005-Ab-1/ GM-Tg-bovg-IP0005-Ab-2; GM-Tg-equg-IP0005-Ab-1/ GM-Tg-equg-IP0005-Ab-2
Products NameAnti-HMGCR monoclonal antibody
Target NameHMGCR
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
Products descriptionPre-made anti-HMGCR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

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    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0005-Ag-1Recombinant multi-species HMDH/ HMGCR/ LDLCQ3 protein
    ORF Viral VectorpGMLPm004787mouse Hmgcr Lentivirus plasmid
    ORF Viral VectorvGMLPm004787mouse Hmgcr Lentivirus particle

    Target information

    Target IDGM-IP0005
    Target NameHMGCR
    Gene ID3156,15357,25675,705479,479182,101098922,407159,100065577
    Gene Symbol and Synonyms3H3M,hmg-coa-r,HMG-CoAR,HMGCR,LDLCQ3,MYPLG,Red
    Uniprot AccessionP04035,P51639,A7Z064
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    Gene EnsemblENSG00000113161
    Target ClassificationN/A

    The target: HMGCR, gene name: HMGCR, also named as LDLCQ3. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.