Recombinant multi-species HMDH/ HMGCR/ LDLCQ3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: HMGCR, gene name: HMGCR, also named as LDLCQ3. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-IP0005-Ag-1	Human HMGCR protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-IP0005-Ag-1	Rat HMGCR protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-IP0005-Ag-1	Mouse HMGCR protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-IP0005-Ag-1	Cynomolgus/ Rhesus macaque HMGCR protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-IP0005-Ag-1	Feline HMGCR protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-IP0005-Ag-1	Canine HMGCR protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0005-Ag-1	Bovine HMGCR protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0005-Ag-1	Equine HMGCR protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-IP0005-Ag, GM-Tg-rg-IP0005-Ag, GM-Tg-mg-IP0005-Ag, GM-Tg-cynog-IP0005-Ag, GM-Tg-felg-IP0005-Ag, GM-Tg-cang-IP0005-Ag, GM-Tg-bovg-IP0005-Ag, GM-Tg-equg-IP0005-Ag-1
Products Name	HMGCR protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	HMGCR
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.