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Anti-PDE3A monoclonal antibody
Pre-made anti-PDE3A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PDE3A/PDE3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0012-Ab-1/ GM-Tg-hg-IP0012-Ab-2 | Anti-Human PDE3A monoclonal antibody | Human |
| GM-Tg-rg-IP0012-Ab-1/ GM-Tg-rg-IP0012-Ab-2 | Anti-Rat PDE3A monoclonal antibody | Rat |
| GM-Tg-mg-IP0012-Ab-1/ GM-Tg-mg-IP0012-Ab-2 | Anti-Mouse PDE3A monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0012-Ab-1/ GM-Tg-cynog-IP0012-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDE3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0012-Ab-1/ GM-Tg-felg-IP0012-Ab-2 | Anti-Feline PDE3A monoclonal antibody | Feline |
| GM-Tg-cang-IP0012-Ab-1/ GM-Tg-cang-IP0012-Ab-2 | Anti-Canine PDE3A monoclonal antibody | Canine |
| GM-Tg-bovg-IP0012-Ab-1/ GM-Tg-bovg-IP0012-Ab-2 | Anti-Bovine PDE3A monoclonal antibody | Bovine |
| GM-Tg-equg-IP0012-Ab-1/ GM-Tg-equg-IP0012-Ab-2 | Anti-Equine PDE3A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0012-Ab-1/ GM-Tg-hg-IP0012-Ab-2; GM-Tg-rg-IP0012-Ab-1/ GM-Tg-rg-IP0012-Ab-2; GM-Tg-mg-IP0012-Ab-1/ GM-Tg-mg-IP0012-Ab-2; GM-Tg-cynog-IP0012-Ab-1/ GM-Tg-cynog-IP0012-Ab-2; GM-Tg-felg-IP0012-Ab-1/ GM-Tg-felg-IP0012-Ab-2; GM-Tg-cang-IP0012-Ab-1/ GM-Tg-cang-IP0012-Ab-2; GM-Tg-bovg-IP0012-Ab-1/ GM-Tg-bovg-IP0012-Ab-2; GM-Tg-equg-IP0012-Ab-1/ GM-Tg-equg-IP0012-Ab-2 |
| Products Name | Anti-PDE3A monoclonal antibody |
| Format | mab |
| Target Name | PDE3A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PDE3A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0012-Ag-1 | Recombinant multi-species PDE3A/ CGI-PDE/ CGI-PDE A protein |
Target information
| Target ID | GM-IP0012 |
| Target Name | PDE3A |
| Gene ID | 5139,54611,50678,704524,610836,101088586,536636,100034086 |
| Gene Symbol and Synonyms | A930022O17Rik,CGI-PDE,CGI-PDE A,CGI-PDE-A,HTNB,PDE3A,RNPDE3A |
| Uniprot Accession | Q14432,Q62865 |
| Uniprot Entry Name | PDE3A_HUMAN,PDE3A_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000172572 |
| Target Classification | N/A |
The target: PDE3A, gene name: PDE3A, also named as CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB. This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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