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Anti-SC5A8/ SLC5A8/ AIT monoclonal antibody
Anti-SC5A8/ SLC5A8/ AIT antibody for FACS & in-vivo assay
Go to SLC5A8/SLC5A8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1652-Ab-1/ GM-Tg-hg-MP1652-Ab-2 | Anti-Human SLC5A8 monoclonal antibody | Human |
| GM-Tg-rg-MP1652-Ab-1/ GM-Tg-rg-MP1652-Ab-2 | Anti-Rat SLC5A8 monoclonal antibody | Rat |
| GM-Tg-mg-MP1652-Ab-1/ GM-Tg-mg-MP1652-Ab-2 | Anti-Mouse SLC5A8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1652-Ab-1/ GM-Tg-cynog-MP1652-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC5A8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1652-Ab-1/ GM-Tg-felg-MP1652-Ab-2 | Anti-Feline SLC5A8 monoclonal antibody | Feline |
| GM-Tg-cang-MP1652-Ab-1/ GM-Tg-cang-MP1652-Ab-2 | Anti-Canine SLC5A8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1652-Ab-1/ GM-Tg-bovg-MP1652-Ab-2 | Anti-Bovine SLC5A8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1652-Ab-1/ GM-Tg-equg-MP1652-Ab-2 | Anti-Equine SLC5A8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1652-Ab-1/ GM-Tg-hg-MP1652-Ab-2; GM-Tg-rg-MP1652-Ab-1/ GM-Tg-rg-MP1652-Ab-2; GM-Tg-mg-MP1652-Ab-1/ GM-Tg-mg-MP1652-Ab-2; GM-Tg-cynog-MP1652-Ab-1/ GM-Tg-cynog-MP1652-Ab-2; GM-Tg-felg-MP1652-Ab-1/ GM-Tg-felg-MP1652-Ab-2; GM-Tg-cang-MP1652-Ab-1/ GM-Tg-cang-MP1652-Ab-2; GM-Tg-bovg-MP1652-Ab-1/ GM-Tg-bovg-MP1652-Ab-2; GM-Tg-equg-MP1652-Ab-1/ GM-Tg-equg-MP1652-Ab-2 |
| Products Name | Anti-SLC5A8 monoclonal antibody |
| Format | mab |
| Target Name | SLC5A8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC5A8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SC5A8/ SLC5A8/ AIT VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1652 |
| Target Name | SLC5A8 |
| Gene ID | 160728,216225,500820,696335,482626,101098475,615734,100146994 |
| Gene Symbol and Synonyms | AIT,RGD1564146,SLC5A8,SMCT,SMCT1 |
| Uniprot Accession | Q8N695 |
| Uniprot Entry Name | SC5A8_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000256870 |
| Target Classification | N/A |
The target: SLC5A8, gene name: SLC5A8, also named as AIT, SMCT, SMCT1. SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
