Anti-SC5A8/ SLC5A8/ AIT monoclonal antibody

Anti-SC5A8/ SLC5A8/ AIT antibody for FACS & in-vivo assay

Target products collectionGo to SLC5A8/SLC5A8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1652-Ab-1/ GM-Tg-hg-MP1652-Ab-2Anti-Human SLC5A8 monoclonal antibodyHuman
GM-Tg-rg-MP1652-Ab-1/ GM-Tg-rg-MP1652-Ab-2Anti-Rat SLC5A8 monoclonal antibodyRat
GM-Tg-mg-MP1652-Ab-1/ GM-Tg-mg-MP1652-Ab-2Anti-Mouse SLC5A8 monoclonal antibodyMouse
GM-Tg-cynog-MP1652-Ab-1/ GM-Tg-cynog-MP1652-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC5A8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1652-Ab-1/ GM-Tg-felg-MP1652-Ab-2Anti-Feline SLC5A8 monoclonal antibodyFeline
GM-Tg-cang-MP1652-Ab-1/ GM-Tg-cang-MP1652-Ab-2Anti-Canine SLC5A8 monoclonal antibodyCanine
GM-Tg-bovg-MP1652-Ab-1/ GM-Tg-bovg-MP1652-Ab-2Anti-Bovine SLC5A8 monoclonal antibodyBovine
GM-Tg-equg-MP1652-Ab-1/ GM-Tg-equg-MP1652-Ab-2Anti-Equine SLC5A8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1652-Ab-1/ GM-Tg-hg-MP1652-Ab-2; GM-Tg-rg-MP1652-Ab-1/ GM-Tg-rg-MP1652-Ab-2;
GM-Tg-mg-MP1652-Ab-1/ GM-Tg-mg-MP1652-Ab-2; GM-Tg-cynog-MP1652-Ab-1/ GM-Tg-cynog-MP1652-Ab-2;
GM-Tg-felg-MP1652-Ab-1/ GM-Tg-felg-MP1652-Ab-2; GM-Tg-cang-MP1652-Ab-1/ GM-Tg-cang-MP1652-Ab-2;
GM-Tg-bovg-MP1652-Ab-1/ GM-Tg-bovg-MP1652-Ab-2; GM-Tg-equg-MP1652-Ab-1/ GM-Tg-equg-MP1652-Ab-2
Products NameAnti-SLC5A8 monoclonal antibody
Formatmab
Target NameSLC5A8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC5A8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SC5A8/ SLC5A8/ AIT VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1652
    Target NameSLC5A8
    Gene ID160728,216225,500820,696335,482626,101098475,615734,100146994
    Gene Symbol and SynonymsAIT,RGD1564146,SLC5A8,SMCT,SMCT1
    Uniprot AccessionQ8N695
    Uniprot Entry NameSC5A8_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000256870
    Target ClassificationN/A

    The target: SLC5A8, gene name: SLC5A8, also named as AIT, SMCT, SMCT1. SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.