Anti-MANBA/ MANB1 monoclonal antibody

Anti-MANBA/ MANB1 antibody for FACS & in-vivo assay

Target products collectionGo to MANBA/MANBA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2583-Ab-1/ GM-Tg-hg-MP2583-Ab-2Anti-Human MANBA monoclonal antibodyHuman
GM-Tg-rg-MP2583-Ab-1/ GM-Tg-rg-MP2583-Ab-2Anti-Rat MANBA monoclonal antibodyRat
GM-Tg-mg-MP2583-Ab-1/ GM-Tg-mg-MP2583-Ab-2Anti-Mouse MANBA monoclonal antibodyMouse
GM-Tg-cynog-MP2583-Ab-1/ GM-Tg-cynog-MP2583-Ab-2Anti-Cynomolgus/ Rhesus macaque MANBA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2583-Ab-1/ GM-Tg-felg-MP2583-Ab-2Anti-Feline MANBA monoclonal antibodyFeline
GM-Tg-cang-MP2583-Ab-1/ GM-Tg-cang-MP2583-Ab-2Anti-Canine MANBA monoclonal antibodyCanine
GM-Tg-bovg-MP2583-Ab-1/ GM-Tg-bovg-MP2583-Ab-2Anti-Bovine MANBA monoclonal antibodyBovine
GM-Tg-equg-MP2583-Ab-1/ GM-Tg-equg-MP2583-Ab-2Anti-Equine MANBA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2583-Ab-1/ GM-Tg-hg-MP2583-Ab-2; GM-Tg-rg-MP2583-Ab-1/ GM-Tg-rg-MP2583-Ab-2;
GM-Tg-mg-MP2583-Ab-1/ GM-Tg-mg-MP2583-Ab-2; GM-Tg-cynog-MP2583-Ab-1/ GM-Tg-cynog-MP2583-Ab-2;
GM-Tg-felg-MP2583-Ab-1/ GM-Tg-felg-MP2583-Ab-2; GM-Tg-cang-MP2583-Ab-1/ GM-Tg-cang-MP2583-Ab-2;
GM-Tg-bovg-MP2583-Ab-1/ GM-Tg-bovg-MP2583-Ab-2; GM-Tg-equg-MP2583-Ab-1/ GM-Tg-equg-MP2583-Ab-2
Products NameAnti-MANBA monoclonal antibody
Formatmab
Target NameMANBA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MANBA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MANBA/ MANB1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2583
    Target NameMANBA
    Gene ID4126,110173,310864,712531,487883,101085628,281909,100067947
    Gene Symbol and Synonyms2410030O07Rik,B930014J03Rik,Bmn,MANB1,MANBA
    Uniprot AccessionO00462,Q4FZV0,Q29444
    Uniprot Entry NameMANBA_HUMAN,MANBA_RAT,MANBA_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000109323
    Target ClassificationN/A

    The target: MANBA, gene name: MANBA, also named as MANB1. This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.