Anti-SEPP1/ SELENOP/ SELP functional antibody

Anti-SEPP1/ SELENOP/ SELP functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SELENOP/SELENOP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0464-Ab-1/ GM-Tg-hg-SE0464-Ab-2Anti-Human SELENOP monoclonal antibodyHuman
GM-Tg-rg-SE0464-Ab-1/ GM-Tg-rg-SE0464-Ab-2Anti-Rat SELENOP monoclonal antibodyRat
GM-Tg-mg-SE0464-Ab-1/ GM-Tg-mg-SE0464-Ab-2Anti-Mouse SELENOP monoclonal antibodyMouse
GM-Tg-cynog-SE0464-Ab-1/ GM-Tg-cynog-SE0464-Ab-2Anti-Cynomolgus/ Rhesus macaque SELENOP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0464-Ab-1/ GM-Tg-felg-SE0464-Ab-2Anti-Feline SELENOP monoclonal antibodyFeline
GM-Tg-cang-SE0464-Ab-1/ GM-Tg-cang-SE0464-Ab-2Anti-Canine SELENOP monoclonal antibodyCanine
GM-Tg-bovg-SE0464-Ab-1/ GM-Tg-bovg-SE0464-Ab-2Anti-Bovine SELENOP monoclonal antibodyBovine
GM-Tg-equg-SE0464-Ab-1/ GM-Tg-equg-SE0464-Ab-2Anti-Equine SELENOP monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-SE0464-Ab-1/ GM-Tg-hg-SE0464-Ab-2; GM-Tg-rg-SE0464-Ab-1/ GM-Tg-rg-SE0464-Ab-2;
GM-Tg-mg-SE0464-Ab-1/ GM-Tg-mg-SE0464-Ab-2; GM-Tg-cynog-SE0464-Ab-1/ GM-Tg-cynog-SE0464-Ab-2;
GM-Tg-felg-SE0464-Ab-1/ GM-Tg-felg-SE0464-Ab-2; GM-Tg-cang-SE0464-Ab-1/ GM-Tg-cang-SE0464-Ab-2;
GM-Tg-bovg-SE0464-Ab-1/ GM-Tg-bovg-SE0464-Ab-2; GM-Tg-equg-SE0464-Ab-1/ GM-Tg-equg-SE0464-Ab-2
Products NameAnti-SELENOP monoclonal antibody
Target NameSELENOP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-SELENOP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0464-Ag-1Recombinant multi-species SEPP1/ SELENOP/ SELP protein
    ORF Viral VectorvGMLV000211human SELENOP Lentivirus particle
    ORF Viral VectorvGMLP001256human SELENOP Lentivirus particle
    ORF Viral VectorpGMLP001256human SELENOP Lentivirus plasmid
    ORF Viral VectorpGMLV000211human SELENOP Lentivirus plasmid
    ORF Viral VectorpGMLPm001843mouse Selenop Lentivirus plasmid
    ORF Viral VectorvGMLPm001843mouse Selenop Lentivirus particle

    Target information

    Target IDGM-SE0464
    Target NameSELENOP
    Gene ID6414,20363,29360,698917,479346,101093246,282066,100052968
    Gene Symbol and SynonymsD15Ucla1,Se-P,SELENOP,SELP,SeP,SEPP,SEPP1
    Uniprot AccessionP49908,P25236,P49907
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Gene EnsemblENSG00000250722
    Target ClassificationTumor-associated antigen (TAA)

    The target: SELENOP, gene name: SELENOP, also named as SELP, SEPP, SEPP1, SeP. This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.