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Anti-PDE4D/ ACRDYS2/ DPDE3 monoclonal antibody
Anti-PDE4D/ ACRDYS2/ DPDE3 antibody for FACS & in-vivo assay
Go to PDE4D/PDE4D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02001-Ab-1/ GM-Tg-hg-T02001-Ab-2 | Anti-Human PDE4D monoclonal antibody | Human |
| GM-Tg-rg-T02001-Ab-1/ GM-Tg-rg-T02001-Ab-2 | Anti-Rat PDE4D monoclonal antibody | Rat |
| GM-Tg-mg-T02001-Ab-1/ GM-Tg-mg-T02001-Ab-2 | Anti-Mouse PDE4D monoclonal antibody | Mouse |
| GM-Tg-cynog-T02001-Ab-1/ GM-Tg-cynog-T02001-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDE4D monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02001-Ab-1/ GM-Tg-felg-T02001-Ab-2 | Anti-Feline PDE4D monoclonal antibody | Feline |
| GM-Tg-cang-T02001-Ab-1/ GM-Tg-cang-T02001-Ab-2 | Anti-Canine PDE4D monoclonal antibody | Canine |
| GM-Tg-bovg-T02001-Ab-1/ GM-Tg-bovg-T02001-Ab-2 | Anti-Bovine PDE4D monoclonal antibody | Bovine |
| GM-Tg-equg-T02001-Ab-1/ GM-Tg-equg-T02001-Ab-2 | Anti-Equine PDE4D monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02001-Ab-1/ GM-Tg-hg-T02001-Ab-2; GM-Tg-rg-T02001-Ab-1/ GM-Tg-rg-T02001-Ab-2; GM-Tg-mg-T02001-Ab-1/ GM-Tg-mg-T02001-Ab-2; GM-Tg-cynog-T02001-Ab-1/ GM-Tg-cynog-T02001-Ab-2; GM-Tg-felg-T02001-Ab-1/ GM-Tg-felg-T02001-Ab-2; GM-Tg-cang-T02001-Ab-1/ GM-Tg-cang-T02001-Ab-2; GM-Tg-bovg-T02001-Ab-1/ GM-Tg-bovg-T02001-Ab-2; GM-Tg-equg-T02001-Ab-1/ GM-Tg-equg-T02001-Ab-2 |
| Products Name | Anti-PDE4D monoclonal antibody |
| Format | mab |
| Target Name | PDE4D |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDE4D benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PDE4D/ ACRDYS2/ DPDE3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003637 | mouse Pde4d Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003637 | mouse Pde4d Lentivirus particle |
Target information
| Target ID | GM-T02001 |
| Target Name | PDE4D |
| Gene ID | 5144,238871,24627,712180,487221,101092826,539556,100051344 |
| Gene Symbol and Synonyms | 9630011N22Rik,ACRDYS2,DPDE3,HSPDE4D,PDE3/IVd,PDE43,PDE4D,PDE4DN2,STRK1 |
| Uniprot Accession | Q08499,P14270 |
| Uniprot Entry Name | PDE4D_HUMAN,PDE4D_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000113448 |
| Target Classification | N/A |
The target: PDE4D, gene name: PDE4D, also named as ACRDYS2, DPDE3, HSPDE4D, PDE43N2, STRK1, PDE4D. This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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