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Anti-PDE5A monoclonal antibody
Pre-made anti-PDE5A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PDE5A/PDE5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T07663-Ab-1/ GM-Tg-hg-T07663-Ab-2 | Anti-Human PDE5A monoclonal antibody | Human |
| GM-Tg-rg-T07663-Ab-1/ GM-Tg-rg-T07663-Ab-2 | Anti-Rat PDE5A monoclonal antibody | Rat |
| GM-Tg-mg-T07663-Ab-1/ GM-Tg-mg-T07663-Ab-2 | Anti-Mouse PDE5A monoclonal antibody | Mouse |
| GM-Tg-cynog-T07663-Ab-1/ GM-Tg-cynog-T07663-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDE5A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T07663-Ab-1/ GM-Tg-felg-T07663-Ab-2 | Anti-Feline PDE5A monoclonal antibody | Feline |
| GM-Tg-cang-T07663-Ab-1/ GM-Tg-cang-T07663-Ab-2 | Anti-Canine PDE5A monoclonal antibody | Canine |
| GM-Tg-bovg-T07663-Ab-1/ GM-Tg-bovg-T07663-Ab-2 | Anti-Bovine PDE5A monoclonal antibody | Bovine |
| GM-Tg-equg-T07663-Ab-1/ GM-Tg-equg-T07663-Ab-2 | Anti-Equine PDE5A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T07663-Ab-1/ GM-Tg-hg-T07663-Ab-2; GM-Tg-rg-T07663-Ab-1/ GM-Tg-rg-T07663-Ab-2; GM-Tg-mg-T07663-Ab-1/ GM-Tg-mg-T07663-Ab-2; GM-Tg-cynog-T07663-Ab-1/ GM-Tg-cynog-T07663-Ab-2; GM-Tg-felg-T07663-Ab-1/ GM-Tg-felg-T07663-Ab-2; GM-Tg-cang-T07663-Ab-1/ GM-Tg-cang-T07663-Ab-2; GM-Tg-bovg-T07663-Ab-1/ GM-Tg-bovg-T07663-Ab-2; GM-Tg-equg-T07663-Ab-1/ GM-Tg-equg-T07663-Ab-2 |
| Products Name | Anti-PDE5A monoclonal antibody |
| Format | mab |
| Target Name | PDE5A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PDE5A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T07663-Ag-1 | Recombinant multi-species PDE5A/ CGB-PDE/ CN5A protein |
| ORF Viral Vector | vGMLP001713 | human PDE5A Lentivirus particle |
| ORF Viral Vector | pGMLV000617 | human PDE5A Lentivirus plasmid |
| ORF Viral Vector | vGMLV000617 | human PDE5A Lentivirus particle |
| ORF Viral Vector | pGMLP001713 | human PDE5A Lentivirus plasmid |
Target information
| Target ID | GM-T07663 |
| Target Name | PDE5A |
| Gene ID | 8654,242202,171115,705592,403825,100533976,281972,100072395 |
| Gene Symbol and Synonyms | CGB-PDE,Cgbpde,CN5A,Cn5n,PDE5,PDE5A,Pde5a1,PDE5a2 |
| Uniprot Accession | O76074,O54735,O77746,Q28156 |
| Uniprot Entry Name | PDE5A_HUMAN,PDE5A_RAT,PDE5A_CANLF,PDE5A_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000138735 |
| Target Classification | N/A |
The target: PDE5A, gene name: PDE5A, also named as CGB-PDE, CN5A, PDE5. This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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