Anti-VKOR1/ VKORC1/ EDTP308 functional antibody

Anti-VKOR1/ VKORC1/ EDTP308 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to VKORC1/VKORC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T11843-Ab-1/ GM-Tg-hg-T11843-Ab-2Anti-Human VKORC1 monoclonal antibodyHuman
GM-Tg-rg-T11843-Ab-1/ GM-Tg-rg-T11843-Ab-2Anti-Rat VKORC1 monoclonal antibodyRat
GM-Tg-mg-T11843-Ab-1/ GM-Tg-mg-T11843-Ab-2Anti-Mouse VKORC1 monoclonal antibodyMouse
GM-Tg-cynog-T11843-Ab-1/ GM-Tg-cynog-T11843-Ab-2Anti-Cynomolgus/ Rhesus macaque VKORC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T11843-Ab-1/ GM-Tg-felg-T11843-Ab-2Anti-Feline VKORC1 monoclonal antibodyFeline
GM-Tg-cang-T11843-Ab-1/ GM-Tg-cang-T11843-Ab-2Anti-Canine VKORC1 monoclonal antibodyCanine
GM-Tg-bovg-T11843-Ab-1/ GM-Tg-bovg-T11843-Ab-2Anti-Bovine VKORC1 monoclonal antibodyBovine
GM-Tg-equg-T11843-Ab-1/ GM-Tg-equg-T11843-Ab-2Anti-Equine VKORC1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T11843-Ab-1/ GM-Tg-hg-T11843-Ab-2; GM-Tg-rg-T11843-Ab-1/ GM-Tg-rg-T11843-Ab-2;
GM-Tg-mg-T11843-Ab-1/ GM-Tg-mg-T11843-Ab-2; GM-Tg-cynog-T11843-Ab-1/ GM-Tg-cynog-T11843-Ab-2;
GM-Tg-felg-T11843-Ab-1/ GM-Tg-felg-T11843-Ab-2; GM-Tg-cang-T11843-Ab-1/ GM-Tg-cang-T11843-Ab-2;
GM-Tg-bovg-T11843-Ab-1/ GM-Tg-bovg-T11843-Ab-2; GM-Tg-equg-T11843-Ab-1/ GM-Tg-equg-T11843-Ab-2
Products NameAnti-VKORC1 monoclonal antibody
Target NameVKORC1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-VKORC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

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    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T11843-Ag-1Recombinant multi-species VKOR1/ VKORC1/ EDTP308 protein
    ORF Viral VectorvGMLP003324human VKORC1 Lentivirus particle
    ORF Viral VectorpGMLP003324human VKORC1 Lentivirus plasmid
    ORF Viral VectorpGMLPm000940mouse Vkorc1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000940mouse Vkorc1 Lentivirus particle

    Target information

    Target IDGM-T11843
    Target NameVKORC1
    Gene ID79001,27973,309004,714412,479775,101089669,445422,100063360
    Gene Symbol and SynonymsD7Wsu86e,EDTP308,MST134,MST576,VKCFD2,VKOR,VKORC1
    Uniprot AccessionQ9BQB6,Q6TEK4,Q6B4J2
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    Gene EnsemblENSG00000167397
    Target ClassificationN/A

    The target: VKORC1, gene name: VKORC1, also named as EDTP308, MST134, MST576, VKCFD2, VKOR. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.