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Anti-LEPR/ CD295/ LEP-RD functional antibody
Anti-LEPR/ CD295/ LEP-RD functional antibody for cell culture, ELISA & in-vivo assay
Go to LEPR/LEPR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17163-Ab-1/ GM-Tg-hg-T17163-Ab-2 | Anti-Human LEPR monoclonal antibody | Human |
| GM-Tg-rg-T17163-Ab-1/ GM-Tg-rg-T17163-Ab-2 | Anti-Rat LEPR monoclonal antibody | Rat |
| GM-Tg-mg-T17163-Ab-1/ GM-Tg-mg-T17163-Ab-2 | Anti-Mouse LEPR monoclonal antibody | Mouse |
| GM-Tg-cynog-T17163-Ab-1/ GM-Tg-cynog-T17163-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LEPR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17163-Ab-1/ GM-Tg-felg-T17163-Ab-2 | Anti-Feline LEPR monoclonal antibody | Feline |
| GM-Tg-cang-T17163-Ab-1/ GM-Tg-cang-T17163-Ab-2 | Anti-Canine LEPR monoclonal antibody | Canine |
| GM-Tg-bovg-T17163-Ab-1/ GM-Tg-bovg-T17163-Ab-2 | Anti-Bovine LEPR monoclonal antibody | Bovine |
| GM-Tg-equg-T17163-Ab-1/ GM-Tg-equg-T17163-Ab-2 | Anti-Equine LEPR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17163-Ab-1/ GM-Tg-hg-T17163-Ab-2; GM-Tg-rg-T17163-Ab-1/ GM-Tg-rg-T17163-Ab-2; GM-Tg-mg-T17163-Ab-1/ GM-Tg-mg-T17163-Ab-2; GM-Tg-cynog-T17163-Ab-1/ GM-Tg-cynog-T17163-Ab-2; GM-Tg-felg-T17163-Ab-1/ GM-Tg-felg-T17163-Ab-2; GM-Tg-cang-T17163-Ab-1/ GM-Tg-cang-T17163-Ab-2; GM-Tg-bovg-T17163-Ab-1/ GM-Tg-bovg-T17163-Ab-2; GM-Tg-equg-T17163-Ab-1/ GM-Tg-equg-T17163-Ab-2 |
| Products Name | Anti-LEPR monoclonal antibody |
| Format | mab |
| Target Name | LEPR |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LEPR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-343 | Pre-Made Mibavademab biosimilar, Whole mAb, Anti-LEPR Antibody: Anti-CD295/OB-R/OBR therapeutic antibody |
| Target Antigen | GM-Tg-g-T17163-Ag-1 | Recombinant multi-species LEPR/ CD295/ LEP-RD protein |
Target information
| Target ID | GM-T17163 |
| Target Name | LEPR |
| Gene ID | 3953,16847,24536,574126,450207,101085646,497205,100069504 |
| Gene Symbol and Synonyms | CD295,db,diabetes,Fa,LEP-R,LEPR,Leprb,LEPRD,LEPROT,Modb1,OB-R,OB-RGRP,Ob-RM,obese-like,obl,OBR,ObRb |
| Uniprot Accession | P48357,Q62959,Q9MYL0 |
| Uniprot Entry Name | LEPR_HUMAN,LEPR_MACMU,LEPR_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000116678 |
| Target Classification | N/A |
The target: LEPR, gene name: LEPR, also named as CD295, LEP-RD, OB-R, OBR, LEPR. The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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