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Anti-ICAM1/ BB2/ CD54 monoclonal antibody
Anti-ICAM1/ BB2/ CD54 antibody for FACS & in-vivo assay
Go to ICAM1/ICAM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T26203-Ab-1/ GM-Tg-hg-T26203-Ab-2 | Anti-Human ICAM1 monoclonal antibody | Human |
| GM-Tg-rg-T26203-Ab-1/ GM-Tg-rg-T26203-Ab-2 | Anti-Rat ICAM1 monoclonal antibody | Rat |
| GM-Tg-mg-T26203-Ab-1/ GM-Tg-mg-T26203-Ab-2 | Anti-Mouse ICAM1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T26203-Ab-1/ GM-Tg-cynog-T26203-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ICAM1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T26203-Ab-1/ GM-Tg-felg-T26203-Ab-2 | Anti-Feline ICAM1 monoclonal antibody | Feline |
| GM-Tg-cang-T26203-Ab-1/ GM-Tg-cang-T26203-Ab-2 | Anti-Canine ICAM1 monoclonal antibody | Canine |
| GM-Tg-bovg-T26203-Ab-1/ GM-Tg-bovg-T26203-Ab-2 | Anti-Bovine ICAM1 monoclonal antibody | Bovine |
| GM-Tg-equg-T26203-Ab-1/ GM-Tg-equg-T26203-Ab-2 | Anti-Equine ICAM1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T26203-Ab-1/ GM-Tg-hg-T26203-Ab-2; GM-Tg-rg-T26203-Ab-1/ GM-Tg-rg-T26203-Ab-2; GM-Tg-mg-T26203-Ab-1/ GM-Tg-mg-T26203-Ab-2; GM-Tg-cynog-T26203-Ab-1/ GM-Tg-cynog-T26203-Ab-2; GM-Tg-felg-T26203-Ab-1/ GM-Tg-felg-T26203-Ab-2; GM-Tg-cang-T26203-Ab-1/ GM-Tg-cang-T26203-Ab-2; GM-Tg-bovg-T26203-Ab-1/ GM-Tg-bovg-T26203-Ab-2; GM-Tg-equg-T26203-Ab-1/ GM-Tg-equg-T26203-Ab-2 |
| Products Name | Anti-ICAM1 monoclonal antibody |
| Format | mab |
| Target Name | ICAM1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ICAM1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-835 | |
| Biosimilar | GMP-Bios-INN-834 | Pre-Made Enlimomab Biosimilar, Whole Mab, Anti-ICAM1 Antibody: Anti-BB2/CD54/P3.58 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-064 | Pre-Made Bersanlimab biosimilar, Whole mAb, Anti-ICAM1 Antibody: Anti-BB2/CD54/P3.58 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species ICAM1/ BB2/ CD54 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000135 | Human ICAM1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000135 | Human ICAM1 Adenovirus particle |
| ORF Viral Vector | pGMAAV000306 | house mouse Icam1 AAV plasmid |
| ORF Viral Vector | vGMAAV000306 | house mouse Icam1 AAV particle |
Target information
| Target ID | GM-T26203 |
| Target Name | ICAM1 |
| Gene ID | 3383,15894,712280,403975,101089421,100058207 |
| Gene Symbol and Synonyms | BB2,CD54,Icam-1,ICAM1,Ly-47,MALA-2,P3.58 |
| Uniprot Accession | P05362,Q5NKV6,P33729 |
| Uniprot Entry Name | ICAM1_HUMAN,ICAM1_MACMU,ICAM1_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Pancreas Cancer, asthma, Inflammation, Thrombosis, Chronic Kidney Disease, Kidney transplant rejection, Lupus Glomerulonephritis, Systemic lupus erythematosus (SLE), breast cancer |
| Gene Ensembl | ENSG00000090339 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: ICAM1, gene name: ICAM1, also named as BB2, CD54, P3.58. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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