Anti-STAT3 monoclonal antibody
Pre-made anti-STAT3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to STAT3/STAT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T29130-Ab-1/ GM-Tg-hg-T29130-Ab-2 | Anti-Human STAT3 monoclonal antibody | Human |
GM-Tg-rg-T29130-Ab-1/ GM-Tg-rg-T29130-Ab-2 | Anti-Rat STAT3 monoclonal antibody | Rat |
GM-Tg-mg-T29130-Ab-1/ GM-Tg-mg-T29130-Ab-2 | Anti-Mouse STAT3 monoclonal antibody | Mouse |
GM-Tg-cynog-T29130-Ab-1/ GM-Tg-cynog-T29130-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STAT3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T29130-Ab-1/ GM-Tg-felg-T29130-Ab-2 | Anti-Feline STAT3 monoclonal antibody | Feline |
GM-Tg-cang-T29130-Ab-1/ GM-Tg-cang-T29130-Ab-2 | Anti-Canine STAT3 monoclonal antibody | Canine |
GM-Tg-bovg-T29130-Ab-1/ GM-Tg-bovg-T29130-Ab-2 | Anti-Bovine STAT3 monoclonal antibody | Bovine |
GM-Tg-equg-T29130-Ab-1/ GM-Tg-equg-T29130-Ab-2 | Anti-Equine STAT3 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T29130-Ab-1/ GM-Tg-hg-T29130-Ab-2; GM-Tg-rg-T29130-Ab-1/ GM-Tg-rg-T29130-Ab-2; GM-Tg-mg-T29130-Ab-1/ GM-Tg-mg-T29130-Ab-2; GM-Tg-cynog-T29130-Ab-1/ GM-Tg-cynog-T29130-Ab-2; GM-Tg-felg-T29130-Ab-1/ GM-Tg-felg-T29130-Ab-2; GM-Tg-cang-T29130-Ab-1/ GM-Tg-cang-T29130-Ab-2; GM-Tg-bovg-T29130-Ab-1/ GM-Tg-bovg-T29130-Ab-2; GM-Tg-equg-T29130-Ab-1/ GM-Tg-equg-T29130-Ab-2 |
Products Name | Anti-STAT3 monoclonal antibody |
Format | mab |
Target Name | STAT3 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-STAT3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T29130-Ag-1 | Recombinant multi-species STAT3/ ADMIO/ ADMIO1 protein |
ORF Viral Vector | vGMAD000377 | human STAT3 Adenovirus particle |
ORF Viral Vector | pGMLV000031 | human STAT3 Lentivirus plasmid |
ORF Viral Vector | pGMLV000030 | human STAT3 Lentivirus plasmid |
ORF Viral Vector | vGMLV000031 | human STAT3 Lentivirus particle |
ORF Viral Vector | vGMLV000030 | human STAT3 Lentivirus particle |
ORF Viral Vector | pGMAD000377 | human STAT3 Adenovirus plasmid |
ORF Viral Vector | pGMLV000818 | house mouse Stat3 Lentivirus plasmid |
ORF Viral Vector | pGMAD000253 | rat Stat3 Adenovirus plasmid |
ORF Viral Vector | pGMAD000541 | Norway rat Stat3 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000145 | mouse Stat3 AAV plasmid |
ORF Viral Vector | vGMLV000818 | house mouse Stat3 Lentivirus particle |
ORF Viral Vector | vGMAD000253 | rat Stat3 Adenovirus particle |
ORF Viral Vector | vGMAD000541 | Norway rat Stat3 Adenovirus particle |
ORF Viral Vector | vGMAAV000145 | mouse Stat3 AAV particle |
Target information
Target ID | GM-T29130 |
Target Name | STAT3 |
Gene ID | 6774,20848,25125,574128,490967,101095698,508541,100034011 |
Gene Symbol and Synonyms | 1110034C02Rik,ADMIO,ADMIO1,APRF,HIES,STAT3 |
Uniprot Accession | P40763,P52631,P61635 |
Uniprot Entry Name | STAT3_HUMAN,STAT3_RAT,STAT3_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | Cancer |
Gene Ensembl | ENSG00000168610 |
Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: STAT3, gene name: STAT3, also named as ADMIO, ADMIO1, APRF, HIES. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.