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STAT3: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of STAT3. The page also collects GeneMedi's different modalities and formats products for STAT3 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the STAT3 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]

Target IDGM-T29130
Target NameSTAT3
Gene ID6774,20848,25125,574128,490967,101095698,508541,100034011
Gene Symbol and Synonyms1110034C02Rik,ADMIO,ADMIO1,APRF,HIES,STAT3
Uniprot AccessionP40763,P52631,P61635
Protein Sub-locationIntrocelluar Protein
CategoryTherapeutics Target, Immuno-oncology Target
Gene EnsemblENSG00000168610
Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

Pre-made anti-STAT3 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-STAT3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-STAT3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-STAT3 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabTherapeutics Target antibodyDetail

Recombinant multi-species STAT3/ ADMIO/ ADMIO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STAT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
STAT3 proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail

Pre-made STAT3 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMAD000377human STAT3 Adenovirus particleNM_139276HumanAdenovirus particleDetail
pGMLV000031human STAT3 Lentivirus plasmidNM_139276HumanLentivirus plasmidDetail
pGMLV000030human STAT3 Lentivirus plasmidNM_139276.2HumanLentivirus plasmidDetail
vGMLV000031human STAT3 Lentivirus particleNM_139276HumanLentivirus particleDetail
vGMLV000030human STAT3 Lentivirus particleNM_139276.2HumanLentivirus particleDetail
pGMAD000377human STAT3 Adenovirus plasmidNM_139276HumanAdenovirus plasmidDetail
pGMLV000818house mouse Stat3 Lentivirus plasmidNM_213659.3House MouseLentivirus plasmidDetail
pGMAD000253rat Stat3 Adenovirus plasmidNM_012747.2RatAdenovirus plasmidDetail
pGMAD000541Norway rat Stat3 Adenovirus plasmidNM_012747.2Norway RatAdenovirus plasmidDetail
pGMAAV000145mouse Stat3 AAV plasmidNM_213659.3MouseAAV plasmidDetail
vGMLV000818house mouse Stat3 Lentivirus particleNM_213659.3House MouseLentivirus particleDetail
vGMAD000253rat Stat3 Adenovirus particleNM_012747.2RatAdenovirus particleDetail
vGMAD000541Norway rat Stat3 Adenovirus particleNM_012747.2Norway RatAdenovirus particleDetail
vGMAAV000145mouse Stat3 AAV particleNM_213659.3MouseAAV particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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