STAT3: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of STAT3. The page also collects GeneMedi's different modalities and formats products for STAT3 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the STAT3 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Target ID | GM-T29130 |
Target Name | STAT3 |
Gene ID | 6774,20848,25125,574128,490967,101095698,508541,100034011 |
Gene Symbol and Synonyms | 1110034C02Rik,ADMIO,ADMIO1,APRF,HIES,STAT3 |
Uniprot Accession | P40763,P52631,P61635 |
Uniprot Entry Name | STAT3_HUMAN,STAT3_RAT,STAT3_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | Cancer |
Gene Ensembl | ENSG00000168610 |
Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
Pre-made anti-STAT3 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-STAT3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-STAT3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-STAT3 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species STAT3/ ADMIO/ ADMIO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STAT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
STAT3 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made STAT3 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAD000377 | human STAT3 Adenovirus particle | NM_139276 | Human | Adenovirus particle | Detail |
pGMLV000031 | human STAT3 Lentivirus plasmid | NM_139276 | Human | Lentivirus plasmid | Detail |
pGMLV000030 | human STAT3 Lentivirus plasmid | NM_139276.2 | Human | Lentivirus plasmid | Detail |
vGMLV000031 | human STAT3 Lentivirus particle | NM_139276 | Human | Lentivirus particle | Detail |
vGMLV000030 | human STAT3 Lentivirus particle | NM_139276.2 | Human | Lentivirus particle | Detail |
pGMAD000377 | human STAT3 Adenovirus plasmid | NM_139276 | Human | Adenovirus plasmid | Detail |
pGMLV000818 | house mouse Stat3 Lentivirus plasmid | NM_213659.3 | House Mouse | Lentivirus plasmid | Detail |
pGMAD000253 | rat Stat3 Adenovirus plasmid | NM_012747.2 | Rat | Adenovirus plasmid | Detail |
pGMAD000541 | Norway rat Stat3 Adenovirus plasmid | NM_012747.2 | Norway Rat | Adenovirus plasmid | Detail |
pGMAAV000145 | mouse Stat3 AAV plasmid | NM_213659.3 | Mouse | AAV plasmid | Detail |
vGMLV000818 | house mouse Stat3 Lentivirus particle | NM_213659.3 | House Mouse | Lentivirus particle | Detail |
vGMAD000253 | rat Stat3 Adenovirus particle | NM_012747.2 | Rat | Adenovirus particle | Detail |
vGMAD000541 | Norway rat Stat3 Adenovirus particle | NM_012747.2 | Norway Rat | Adenovirus particle | Detail |
vGMAAV000145 | mouse Stat3 AAV particle | NM_213659.3 | Mouse | AAV particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.