Anti-CALM monoclonal antibody

Pre-made anti-CALM monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to CALM/CALM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T39610-Ab-1/ GM-Tg-hg-T39610-Ab-2Anti-Human CALM/CALM2 monoclonal antibodyHuman
GM-Tg-rg-T39610-Ab-1/ GM-Tg-rg-T39610-Ab-2Anti-Rat CALM/CALM2 monoclonal antibodyRat
GM-Tg-mg-T39610-Ab-1/ GM-Tg-mg-T39610-Ab-2Anti-Mouse CALM/CALM2 monoclonal antibodyMouse
GM-Tg-cynog-T39610-Ab-1/ GM-Tg-cynog-T39610-Ab-2Anti-Cynomolgus/ Rhesus macaque CALM/CALM2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T39610-Ab-1/ GM-Tg-felg-T39610-Ab-2Anti-Feline CALM/CALM2 monoclonal antibodyFeline
GM-Tg-cang-T39610-Ab-1/ GM-Tg-cang-T39610-Ab-2Anti-Canine CALM/CALM2 monoclonal antibodyCanine
GM-Tg-bovg-T39610-Ab-1/ GM-Tg-bovg-T39610-Ab-2Anti-Bovine CALM/CALM2 monoclonal antibodyBovine
GM-Tg-equg-T39610-Ab-1/ GM-Tg-equg-T39610-Ab-2Anti-Equine CALM/CALM2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T39610-Ab-1/ GM-Tg-hg-T39610-Ab-2; GM-Tg-rg-T39610-Ab-1/ GM-Tg-rg-T39610-Ab-2;
GM-Tg-mg-T39610-Ab-1/ GM-Tg-mg-T39610-Ab-2; GM-Tg-cynog-T39610-Ab-1/ GM-Tg-cynog-T39610-Ab-2;
GM-Tg-felg-T39610-Ab-1/ GM-Tg-felg-T39610-Ab-2; GM-Tg-cang-T39610-Ab-1/ GM-Tg-cang-T39610-Ab-2;
GM-Tg-bovg-T39610-Ab-1/ GM-Tg-bovg-T39610-Ab-2; GM-Tg-equg-T39610-Ab-1/ GM-Tg-equg-T39610-Ab-2
Products NameAnti-CALM/CALM2 monoclonal antibody
Formatmab
Target NameCALM
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-CALM monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T39610-Ag-1Recombinant multi-species CALM2/ CALM/ CALML2 protein
    ORF Viral VectorpGMLPm000035mouse Calm2 Lentivirus plasmid
    ORF Viral VectorvGMLPm000035mouse Calm2 Lentivirus particle


    Target information

    Target IDGM-T39610
    Target NameCALM
    Gene ID805,12314,50663,715270,474584,101081534,100297344,100629145
    Gene Symbol and Synonyms1500001E21Rik,CALM,CALM2,CALM3,CALML2,calmodulin,caM,CAM1,Cam2,CAM3,Camb,CAMC,CAMII,CAMIII,LQT15,PHKD,PHKD2
    Uniprot AccessionP0DP24,P0DP30
    Uniprot Entry NameCALM2_HUMAN,CALM2_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000143933
    Target ClassificationN/A

    The target: CALM, gene name: CALM2, also named as CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM. This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.