Anti-CALM monoclonal antibody
Pre-made anti-CALM monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CALM/CALM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T39610-Ab-1/ GM-Tg-hg-T39610-Ab-2 | Anti-Human CALM/CALM2 monoclonal antibody | Human |
GM-Tg-rg-T39610-Ab-1/ GM-Tg-rg-T39610-Ab-2 | Anti-Rat CALM/CALM2 monoclonal antibody | Rat |
GM-Tg-mg-T39610-Ab-1/ GM-Tg-mg-T39610-Ab-2 | Anti-Mouse CALM/CALM2 monoclonal antibody | Mouse |
GM-Tg-cynog-T39610-Ab-1/ GM-Tg-cynog-T39610-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALM/CALM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T39610-Ab-1/ GM-Tg-felg-T39610-Ab-2 | Anti-Feline CALM/CALM2 monoclonal antibody | Feline |
GM-Tg-cang-T39610-Ab-1/ GM-Tg-cang-T39610-Ab-2 | Anti-Canine CALM/CALM2 monoclonal antibody | Canine |
GM-Tg-bovg-T39610-Ab-1/ GM-Tg-bovg-T39610-Ab-2 | Anti-Bovine CALM/CALM2 monoclonal antibody | Bovine |
GM-Tg-equg-T39610-Ab-1/ GM-Tg-equg-T39610-Ab-2 | Anti-Equine CALM/CALM2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T39610-Ab-1/ GM-Tg-hg-T39610-Ab-2; GM-Tg-rg-T39610-Ab-1/ GM-Tg-rg-T39610-Ab-2; GM-Tg-mg-T39610-Ab-1/ GM-Tg-mg-T39610-Ab-2; GM-Tg-cynog-T39610-Ab-1/ GM-Tg-cynog-T39610-Ab-2; GM-Tg-felg-T39610-Ab-1/ GM-Tg-felg-T39610-Ab-2; GM-Tg-cang-T39610-Ab-1/ GM-Tg-cang-T39610-Ab-2; GM-Tg-bovg-T39610-Ab-1/ GM-Tg-bovg-T39610-Ab-2; GM-Tg-equg-T39610-Ab-1/ GM-Tg-equg-T39610-Ab-2 |
Products Name | Anti-CALM/CALM2 monoclonal antibody |
Format | mab |
Target Name | CALM |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-CALM monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T39610-Ag-1 | Recombinant multi-species CALM2/ CALM/ CALML2 protein |
ORF Viral Vector | pGMLPm000035 | mouse Calm2 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000035 | mouse Calm2 Lentivirus particle |
Target information
Target ID | GM-T39610 |
Target Name | CALM |
Gene ID | 805,12314,50663,715270,474584,101081534,100297344,100629145 |
Gene Symbol and Synonyms | 1500001E21Rik,CALM,CALM2,CALM3,CALML2,calmodulin,caM,CAM1,Cam2,CAM3,Camb,CAMC,CAMII,CAMIII,LQT15,PHKD,PHKD2 |
Uniprot Accession | P0DP24,P0DP30 |
Uniprot Entry Name | CALM2_HUMAN,CALM2_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000143933 |
Target Classification | N/A |
The target: CALM, gene name: CALM2, also named as CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM. This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.