Recombinant multi-species CALM2/ CALM/ CALML2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CALM/CALM2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CALM, gene name: CALM2, also named as CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM. This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T39610-Ag-1	Human CALM/CALM2 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T39610-Ag-1	Rat CALM/CALM2 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T39610-Ag-1	Mouse CALM/CALM2 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T39610-Ag-1	Cynomolgus/ Rhesus macaque CALM/CALM2 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T39610-Ag-1	Feline CALM/CALM2 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T39610-Ag-1	Canine CALM/CALM2 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T39610-Ag-1	Bovine CALM/CALM2 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T39610-Ag-1	Equine CALM/CALM2 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T39610-Ag, GM-Tg-rg-T39610-Ag, GM-Tg-mg-T39610-Ag, GM-Tg-cynog-T39610-Ag, GM-Tg-felg-T39610-Ag, GM-Tg-cang-T39610-Ag, GM-Tg-bovg-T39610-Ag, GM-Tg-equg-T39610-Ag-1
Products Name	CALM/CALM2 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CALM
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CALM/CALM2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.