Anti-PRKCG monoclonal antibody

Pre-made anti-PRKCG monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PRKCG/PRKCG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T47107-Ab-1/ GM-Tg-hg-T47107-Ab-2Anti-Human PRKCG monoclonal antibodyHuman
GM-Tg-rg-T47107-Ab-1/ GM-Tg-rg-T47107-Ab-2Anti-Rat PRKCG monoclonal antibodyRat
GM-Tg-mg-T47107-Ab-1/ GM-Tg-mg-T47107-Ab-2Anti-Mouse PRKCG monoclonal antibodyMouse
GM-Tg-cynog-T47107-Ab-1/ GM-Tg-cynog-T47107-Ab-2Anti-Cynomolgus/ Rhesus macaque PRKCG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T47107-Ab-1/ GM-Tg-felg-T47107-Ab-2Anti-Feline PRKCG monoclonal antibodyFeline
GM-Tg-cang-T47107-Ab-1/ GM-Tg-cang-T47107-Ab-2Anti-Canine PRKCG monoclonal antibodyCanine
GM-Tg-bovg-T47107-Ab-1/ GM-Tg-bovg-T47107-Ab-2Anti-Bovine PRKCG monoclonal antibodyBovine
GM-Tg-equg-T47107-Ab-1/ GM-Tg-equg-T47107-Ab-2Anti-Equine PRKCG monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T47107-Ab-1/ GM-Tg-hg-T47107-Ab-2; GM-Tg-rg-T47107-Ab-1/ GM-Tg-rg-T47107-Ab-2;
GM-Tg-mg-T47107-Ab-1/ GM-Tg-mg-T47107-Ab-2; GM-Tg-cynog-T47107-Ab-1/ GM-Tg-cynog-T47107-Ab-2;
GM-Tg-felg-T47107-Ab-1/ GM-Tg-felg-T47107-Ab-2; GM-Tg-cang-T47107-Ab-1/ GM-Tg-cang-T47107-Ab-2;
GM-Tg-bovg-T47107-Ab-1/ GM-Tg-bovg-T47107-Ab-2; GM-Tg-equg-T47107-Ab-1/ GM-Tg-equg-T47107-Ab-2
Products NameAnti-PRKCG monoclonal antibody
Formatmab
Target NamePRKCG
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PRKCG monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T47107-Ag-1Recombinant multi-species KPCG/ PRKCG/ PKC-gamma protein


    Target information

    Target IDGM-T47107
    Target NamePRKCG
    Gene ID5582,18752,24681,720263,100855828,101082196,282002,100062549
    Gene Symbol and SynonymsPKC,PKC-gamma,PKCC,PKCG,PKCgamma,PKCI,PKCI(3),Prkc,Prkcc,PRKCG,RATPKCI,SCA14
    Uniprot AccessionP05129,P63319,P05128
    Uniprot Entry NameKPCG_HUMAN,KPCG_RAT,KPCG_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000126583
    Target ClassificationN/A

    The target: PRKCG, gene name: PRKCG, also named as PKC-gamma, PKCC, PKCG, PKCI(3), PKCgamma, SCA14. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.