Anti-PRKCG monoclonal antibody
Pre-made anti-PRKCG monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T47107-Ab-1/ GM-Tg-hg-T47107-Ab-2 | Anti-Human PRKCG monoclonal antibody | Human |
GM-Tg-rg-T47107-Ab-1/ GM-Tg-rg-T47107-Ab-2 | Anti-Rat PRKCG monoclonal antibody | Rat |
GM-Tg-mg-T47107-Ab-1/ GM-Tg-mg-T47107-Ab-2 | Anti-Mouse PRKCG monoclonal antibody | Mouse |
GM-Tg-cynog-T47107-Ab-1/ GM-Tg-cynog-T47107-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRKCG monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T47107-Ab-1/ GM-Tg-felg-T47107-Ab-2 | Anti-Feline PRKCG monoclonal antibody | Feline |
GM-Tg-cang-T47107-Ab-1/ GM-Tg-cang-T47107-Ab-2 | Anti-Canine PRKCG monoclonal antibody | Canine |
GM-Tg-bovg-T47107-Ab-1/ GM-Tg-bovg-T47107-Ab-2 | Anti-Bovine PRKCG monoclonal antibody | Bovine |
GM-Tg-equg-T47107-Ab-1/ GM-Tg-equg-T47107-Ab-2 | Anti-Equine PRKCG monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T47107-Ab-1/ GM-Tg-hg-T47107-Ab-2; GM-Tg-rg-T47107-Ab-1/ GM-Tg-rg-T47107-Ab-2; GM-Tg-mg-T47107-Ab-1/ GM-Tg-mg-T47107-Ab-2; GM-Tg-cynog-T47107-Ab-1/ GM-Tg-cynog-T47107-Ab-2; GM-Tg-felg-T47107-Ab-1/ GM-Tg-felg-T47107-Ab-2; GM-Tg-cang-T47107-Ab-1/ GM-Tg-cang-T47107-Ab-2; GM-Tg-bovg-T47107-Ab-1/ GM-Tg-bovg-T47107-Ab-2; GM-Tg-equg-T47107-Ab-1/ GM-Tg-equg-T47107-Ab-2 |
Products Name | Anti-PRKCG monoclonal antibody |
Format | mab |
Target Name | PRKCG |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-PRKCG monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T47107-Ag-1 | Recombinant multi-species KPCG/ PRKCG/ PKC-gamma protein |
Target information
Target ID | GM-T47107 |
Target Name | PRKCG |
Gene ID | 5582,18752,24681,720263,100855828,101082196,282002,100062549 |
Gene Symbol and Synonyms | PKC,PKC-gamma,PKCC,PKCG,PKCgamma,PKCI,PKCI(3),Prkc,Prkcc,PRKCG,RATPKCI,SCA14 |
Uniprot Accession | P05129,P63319,P05128 |
Uniprot Entry Name | KPCG_HUMAN,KPCG_RAT,KPCG_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000126583 |
Target Classification | N/A |
The target: PRKCG, gene name: PRKCG, also named as PKC-gamma, PKCC, PKCG, PKCI(3), PKCgamma, SCA14. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.