Anti-ADRB2/ ADRB2R/ ADRBR monoclonal antibody

Anti-ADRB2/ ADRB2R/ ADRBR antibody for FACS & in-vivo assay

Target products collectionGo to ADRB2/ADRB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T52522-Ab-1/ GM-Tg-hg-T52522-Ab-2Anti-Human ADRB2 monoclonal antibodyHuman
GM-Tg-rg-T52522-Ab-1/ GM-Tg-rg-T52522-Ab-2Anti-Rat ADRB2 monoclonal antibodyRat
GM-Tg-mg-T52522-Ab-1/ GM-Tg-mg-T52522-Ab-2Anti-Mouse ADRB2 monoclonal antibodyMouse
GM-Tg-cynog-T52522-Ab-1/ GM-Tg-cynog-T52522-Ab-2Anti-Cynomolgus/ Rhesus macaque ADRB2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T52522-Ab-1/ GM-Tg-felg-T52522-Ab-2Anti-Feline ADRB2 monoclonal antibodyFeline
GM-Tg-cang-T52522-Ab-1/ GM-Tg-cang-T52522-Ab-2Anti-Canine ADRB2 monoclonal antibodyCanine
GM-Tg-bovg-T52522-Ab-1/ GM-Tg-bovg-T52522-Ab-2Anti-Bovine ADRB2 monoclonal antibodyBovine
GM-Tg-equg-T52522-Ab-1/ GM-Tg-equg-T52522-Ab-2Anti-Equine ADRB2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T52522-Ab-1/ GM-Tg-hg-T52522-Ab-2; GM-Tg-rg-T52522-Ab-1/ GM-Tg-rg-T52522-Ab-2;
GM-Tg-mg-T52522-Ab-1/ GM-Tg-mg-T52522-Ab-2; GM-Tg-cynog-T52522-Ab-1/ GM-Tg-cynog-T52522-Ab-2;
GM-Tg-felg-T52522-Ab-1/ GM-Tg-felg-T52522-Ab-2; GM-Tg-cang-T52522-Ab-1/ GM-Tg-cang-T52522-Ab-2;
GM-Tg-bovg-T52522-Ab-1/ GM-Tg-bovg-T52522-Ab-2; GM-Tg-equg-T52522-Ab-1/ GM-Tg-equg-T52522-Ab-2
Products NameAnti-ADRB2 monoclonal antibody
Formatmab
Target NameADRB2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ADRB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ADRB2/ ADRB2R/ ADRBR VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003663human ADRB2 Lentivirus particle
    ORF Viral VectorpGMLV000869human ADRB2 Lentivirus plasmid
    ORF Viral VectorvGMLV000869human ADRB2 Lentivirus particle
    ORF Viral VectorpGMLP003663human ADRB2 Lentivirus plasmid
    ORF Viral VectorpGMAD000198mouse Adrb2 Adenovirus plasmid
    ORF Viral VectorpGMAD000594house mouse Adrb2 Adenovirus plasmid
    ORF Viral VectorvGMAD000198mouse Adrb2 Adenovirus particle
    ORF Viral VectorvGMAD000594house mouse Adrb2 Adenovirus particle


    Target information

    Target IDGM-T52522
    Target NameADRB2
    Gene ID154,11555,24176,710146,403910,493767,281605,100060659
    Gene Symbol and SynonymsAdrb-2,ADRB2,ADRB2R,ADRBR,B2AR,Badm,BAR,BETA2AR,Gpcr7
    Uniprot AccessionP07550,P10608,Q28509,P54833,Q9TST5,Q28044
    Uniprot Entry NameADRB2_HUMAN,ADRB2_MACMU,ADRB2_RAT,ADRB2_FELCA,ADRB2_CANLF,ADRB2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000169252
    Target ClassificationGPCR, Tumor-associated antigen (TAA)

    The target: ADRB2, gene name: ADRB2, also named as ADRB2R, ADRBR, B2AR, BAR, BETA2AR. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.