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ADRB2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of ADRB2. The page also collects GeneMedi's different modalities and formats products for ADRB2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the ADRB2 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

Target IDGM-T52522
Target NameADRB2
Gene ID154,11555,24176,710146,403910,493767,281605,100060659
Gene Symbol and SynonymsAdrb-2,ADRB2,ADRB2R,ADRBR,B2AR,Badm,BAR,BETA2AR,Gpcr7
Uniprot AccessionP07550,P10608,Q28509,P54833,Q9TST5,Q28044
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target
Gene EnsemblENSG00000169252
Target ClassificationGPCR, Tumor-associated antigen (TAA)

Pre-made anti-ADRB2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-ADRB2 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-ADRB2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-ADRB2 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail

Multi-species ADRB2/ ADRB2R/ ADRBR VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ADRB2 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
ADRB2 VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing

Pre-made ADRB2 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMLP003663human ADRB2 Lentivirus particleNM_000024HumanLentivirus particleDetail
pGMLV000869human ADRB2 Lentivirus plasmidNM_000024.5HumanLentivirus plasmidDetail
vGMLV000869human ADRB2 Lentivirus particleNM_000024.5HumanLentivirus particleDetail
pGMLP003663human ADRB2 Lentivirus plasmidNM_000024HumanLentivirus plasmidDetail
pGMAD000198mouse Adrb2 Adenovirus plasmidNM_007420MouseAdenovirus plasmidDetail
pGMAD000594house mouse Adrb2 Adenovirus plasmidNM_007420.3House MouseAdenovirus plasmidDetail
vGMAD000198mouse Adrb2 Adenovirus particleNM_007420MouseAdenovirus particleDetail
vGMAD000594house mouse Adrb2 Adenovirus particleNM_007420.3House MouseAdenovirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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