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Anti-ABAT monoclonal antibody
Pre-made anti-ABAT monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ABAT/ABAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59045-Ab-1/ GM-Tg-hg-T59045-Ab-2 | Anti-Human ABAT monoclonal antibody | Human |
| GM-Tg-rg-T59045-Ab-1/ GM-Tg-rg-T59045-Ab-2 | Anti-Rat ABAT monoclonal antibody | Rat |
| GM-Tg-mg-T59045-Ab-1/ GM-Tg-mg-T59045-Ab-2 | Anti-Mouse ABAT monoclonal antibody | Mouse |
| GM-Tg-cynog-T59045-Ab-1/ GM-Tg-cynog-T59045-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ABAT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59045-Ab-1/ GM-Tg-felg-T59045-Ab-2 | Anti-Feline ABAT monoclonal antibody | Feline |
| GM-Tg-cang-T59045-Ab-1/ GM-Tg-cang-T59045-Ab-2 | Anti-Canine ABAT monoclonal antibody | Canine |
| GM-Tg-bovg-T59045-Ab-1/ GM-Tg-bovg-T59045-Ab-2 | Anti-Bovine ABAT monoclonal antibody | Bovine |
| GM-Tg-equg-T59045-Ab-1/ GM-Tg-equg-T59045-Ab-2 | Anti-Equine ABAT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59045-Ab-1/ GM-Tg-hg-T59045-Ab-2; GM-Tg-rg-T59045-Ab-1/ GM-Tg-rg-T59045-Ab-2; GM-Tg-mg-T59045-Ab-1/ GM-Tg-mg-T59045-Ab-2; GM-Tg-cynog-T59045-Ab-1/ GM-Tg-cynog-T59045-Ab-2; GM-Tg-felg-T59045-Ab-1/ GM-Tg-felg-T59045-Ab-2; GM-Tg-cang-T59045-Ab-1/ GM-Tg-cang-T59045-Ab-2; GM-Tg-bovg-T59045-Ab-1/ GM-Tg-bovg-T59045-Ab-2; GM-Tg-equg-T59045-Ab-1/ GM-Tg-equg-T59045-Ab-2 |
| Products Name | Anti-ABAT monoclonal antibody |
| Format | mab |
| Target Name | ABAT |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ABAT monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T59045-Ag-1 | Recombinant multi-species GABT/ ABAT/ GABA-AT protein |
| ORF Viral Vector | vGMLP000658 | human ABAT Lentivirus particle |
| ORF Viral Vector | pGMLP000658 | human ABAT Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002731 | mouse Abat Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002731 | mouse Abat Lentivirus particle |
Target information
| Target ID | GM-T59045 |
| Target Name | ABAT |
| Gene ID | 18,268860,81632,714017,479856,101089064,280969,100051470 |
| Gene Symbol and Synonyms | 9630038C02Rik,ABAT,beta-AlaAT,GABA-AT,GABA-T,Gabaat,GABAT,Gm9851,I54,L-AIBAT,Laibat,NPD009 |
| Uniprot Accession | P80404,P50554,Q9BGI0 |
| Uniprot Entry Name | GABT_HUMAN,GABT_RAT,GABT_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000183044 |
| Target Classification | N/A |
The target: ABAT, gene name: ABAT, also named as GABA-AT, GABAT, NPD009. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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