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Anti-PGFRB/ PDGFRB/ CD140B monoclonal antibody
Anti-PGFRB/ PDGFRB/ CD140B antibody for FACS & in-vivo assay
Go to PDGFRB/PDGFRB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59102-Ab-1/ GM-Tg-hg-T59102-Ab-2 | Anti-Human PDGFRB monoclonal antibody | Human |
| GM-Tg-rg-T59102-Ab-1/ GM-Tg-rg-T59102-Ab-2 | Anti-Rat PDGFRB monoclonal antibody | Rat |
| GM-Tg-mg-T59102-Ab-1/ GM-Tg-mg-T59102-Ab-2 | Anti-Mouse PDGFRB monoclonal antibody | Mouse |
| GM-Tg-cynog-T59102-Ab-1/ GM-Tg-cynog-T59102-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDGFRB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59102-Ab-1/ GM-Tg-felg-T59102-Ab-2 | Anti-Feline PDGFRB monoclonal antibody | Feline |
| GM-Tg-cang-T59102-Ab-1/ GM-Tg-cang-T59102-Ab-2 | Anti-Canine PDGFRB monoclonal antibody | Canine |
| GM-Tg-bovg-T59102-Ab-1/ GM-Tg-bovg-T59102-Ab-2 | Anti-Bovine PDGFRB monoclonal antibody | Bovine |
| GM-Tg-equg-T59102-Ab-1/ GM-Tg-equg-T59102-Ab-2 | Anti-Equine PDGFRB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59102-Ab-1/ GM-Tg-hg-T59102-Ab-2; GM-Tg-rg-T59102-Ab-1/ GM-Tg-rg-T59102-Ab-2; GM-Tg-mg-T59102-Ab-1/ GM-Tg-mg-T59102-Ab-2; GM-Tg-cynog-T59102-Ab-1/ GM-Tg-cynog-T59102-Ab-2; GM-Tg-felg-T59102-Ab-1/ GM-Tg-felg-T59102-Ab-2; GM-Tg-cang-T59102-Ab-1/ GM-Tg-cang-T59102-Ab-2; GM-Tg-bovg-T59102-Ab-1/ GM-Tg-bovg-T59102-Ab-2; GM-Tg-equg-T59102-Ab-1/ GM-Tg-equg-T59102-Ab-2 |
| Products Name | Anti-PDGFRB monoclonal antibody |
| Format | mab |
| Target Name | PDGFRB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDGFRB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-484 | Pre-Made Rinucumab biosimilar, Whole mAb, Anti-PDGFRB Antibody: Anti-IMF1/KOGS/IBGC4/JTK12/PDGFR/PENTT/CD140B/PDGFR1/PDGFR-1 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species PGFRB/ PDGFRB/ CD140B VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T59102-Ag-1 | Platelet-derived growth factor receptor B (PDGFRB) protein |
| ORF Viral Vector | vGMLP005170 | human PDGFRB Lentivirus particle |
| ORF Viral Vector | pGMLP005170 | human PDGFRB Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000115 | mouse Pdgfrb AAV plasmid |
| ORF Viral Vector | vGMAAV000115 | mouse Pdgfrb AAV particle |
Target information
| Target ID | GM-T59102 |
| Target Name | PDGFRB |
| Gene ID | 5159,18596,24629,711353,442985,101084600,527165,100071665 |
| Gene Symbol and Synonyms | CD140B,IBGC4,IMF1,JTK12,KOGS,PDGFR,PDGFR-1,PDGFR1,PDGFRB,PENTT |
| Uniprot Accession | P09619,Q05030,Q6QNF3 |
| Uniprot Entry Name | PGFRB_HUMAN,PGFRB_RAT,PGFRB_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000113721 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: PDGFRB, gene name: PDGFRB, also named as CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT. The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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