PDGFRB: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of PDGFRB. The page also collects GeneMedi's different modalities and formats products for PDGFRB in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the PDGFRB target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
|Gene Symbol and Synonyms||CD140B,IBGC4,IMF1,JTK12,KOGS,PDGFR,PDGFR-1,PDGFR1,PDGFRB,PENTT|
|Uniprot Entry Name||PGFRB_HUMAN,PGFRB_RAT,PGFRB_CANLF|
|Protein Sub-location||Transmembrane Protein|
|Category||Therapeutics Target, INN Index, Cytokine Target|
|Target Classification||Kinase, Tumor-associated antigen (TAA)|
Pre-made PDGFRB-specific INN-index biosimilar (antibody&conjugates)
Anti-PDGFRB therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
|Cat No.||Products Name (INN Index)||INN Name||Previous Name||Target||Format||Detail|
|GMP-Bios-ab-484||Pre-Made Rinucumab biosimilar, Whole mAb, Anti-PDGFRB Antibody: Anti-IMF1/KOGS/IBGC4/JTK12/PDGFR/PENTT/CD140B/PDGFR1/PDGFR-1 therapeutic antibody||Rinucumab||PDGFRB||Whole mAb||Detail|
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-PDGFRB inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-PDGFRB benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-PDGFRB mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-PDGFRB monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody||Detail|
Multi-species PGFRB/ PDGFRB/ CD140B VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDGFRB VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|PDGFRB VLP (virus-like particle)||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Products Developing|
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse Platelet-derived growth factor receptor B (PDGFRB) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene.
|Target||Species||Antigen Product Name||Bioactivity validation of Antigen||Antibody Product Name||Bioactivity validation of Antibodies||Detail|
|PDGFRB||Human, Cynomolgus/Rhesus macaque, rat, mouse||Platelet-derived growth factor receptor B (PDGFRB) protein||Affintiy&bioactivity validated by ELISA, cell culture validated||Anti-PDGFRB monoclonal antibody||Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).||Detail|
Click to check more Cytokine Products
Pre-made PDGFRB viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|vGMLP005170||human PDGFRB Lentivirus particle||NM_002609||Human||Lentivirus particle||Detail|
|pGMLP005170||human PDGFRB Lentivirus plasmid||NM_002609||Human||Lentivirus plasmid||Detail|
|pGMAAV000115||mouse Pdgfrb AAV plasmid||NM_008809.2||Mouse||AAV plasmid||Detail|
|vGMAAV000115||mouse Pdgfrb AAV particle||NM_008809.2||Mouse||AAV particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.