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Anti-PGH1/ COX-1/ PTGS1 functional antibody
Anti-PGH1/ COX-1/ PTGS1 functional antibody for cell culture, ELISA & in-vivo assay
Go to COX-1/PTGS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60529-Ab-1/ GM-Tg-hg-T60529-Ab-2 | Anti-Human COX-1/PTGS1 monoclonal antibody | Human |
| GM-Tg-rg-T60529-Ab-1/ GM-Tg-rg-T60529-Ab-2 | Anti-Rat COX-1/PTGS1 monoclonal antibody | Rat |
| GM-Tg-mg-T60529-Ab-1/ GM-Tg-mg-T60529-Ab-2 | Anti-Mouse COX-1/PTGS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T60529-Ab-1/ GM-Tg-cynog-T60529-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COX-1/PTGS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60529-Ab-1/ GM-Tg-felg-T60529-Ab-2 | Anti-Feline COX-1/PTGS1 monoclonal antibody | Feline |
| GM-Tg-cang-T60529-Ab-1/ GM-Tg-cang-T60529-Ab-2 | Anti-Canine COX-1/PTGS1 monoclonal antibody | Canine |
| GM-Tg-bovg-T60529-Ab-1/ GM-Tg-bovg-T60529-Ab-2 | Anti-Bovine COX-1/PTGS1 monoclonal antibody | Bovine |
| GM-Tg-equg-T60529-Ab-1/ GM-Tg-equg-T60529-Ab-2 | Anti-Equine COX-1/PTGS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60529-Ab-1/ GM-Tg-hg-T60529-Ab-2; GM-Tg-rg-T60529-Ab-1/ GM-Tg-rg-T60529-Ab-2; GM-Tg-mg-T60529-Ab-1/ GM-Tg-mg-T60529-Ab-2; GM-Tg-cynog-T60529-Ab-1/ GM-Tg-cynog-T60529-Ab-2; GM-Tg-felg-T60529-Ab-1/ GM-Tg-felg-T60529-Ab-2; GM-Tg-cang-T60529-Ab-1/ GM-Tg-cang-T60529-Ab-2; GM-Tg-bovg-T60529-Ab-1/ GM-Tg-bovg-T60529-Ab-2; GM-Tg-equg-T60529-Ab-1/ GM-Tg-equg-T60529-Ab-2 |
| Products Name | Anti-COX-1/PTGS1 monoclonal antibody |
| Format | mab |
| Target Name | COX-1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COX-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T60529-Ag-1 | Recombinant multi-species PGH1/ COX-1/ PTGS1 protein |
Target information
| Target ID | GM-T60529 |
| Target Name | COX-1 |
| Gene ID | 5742,19224,24693,698213,403544,101092557,282022,100034087 |
| Gene Symbol and Synonyms | Cox-1,Cox-3,COX1,COX3,PCOX1,PES-1,PGG/HS,PGHS-1,PGHS1,PHS 1,PHS1,PTGHS,PTGS1 |
| Uniprot Accession | P23219,Q63921,Q8HZR1,O62664 |
| Uniprot Entry Name | PGH1_HUMAN,PGH1_RAT,PGH1_CANLF,PGH1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000095303 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: COX-1, gene name: PTGS1, also named as COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS. This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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