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Anti-EPOR/ EPO-R monoclonal antibody
Anti-EPOR/ EPO-R antibody for FACS & in-vivo assay
Go to EPOR/EPOR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T65197-Ab-1/ GM-Tg-hg-T65197-Ab-2 | Anti-Human EPOR monoclonal antibody | Human |
| GM-Tg-rg-T65197-Ab-1/ GM-Tg-rg-T65197-Ab-2 | Anti-Rat EPOR monoclonal antibody | Rat |
| GM-Tg-mg-T65197-Ab-1/ GM-Tg-mg-T65197-Ab-2 | Anti-Mouse EPOR monoclonal antibody | Mouse |
| GM-Tg-cynog-T65197-Ab-1/ GM-Tg-cynog-T65197-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPOR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T65197-Ab-1/ GM-Tg-felg-T65197-Ab-2 | Anti-Feline EPOR monoclonal antibody | Feline |
| GM-Tg-cang-T65197-Ab-1/ GM-Tg-cang-T65197-Ab-2 | Anti-Canine EPOR monoclonal antibody | Canine |
| GM-Tg-bovg-T65197-Ab-1/ GM-Tg-bovg-T65197-Ab-2 | Anti-Bovine EPOR monoclonal antibody | Bovine |
| GM-Tg-equg-T65197-Ab-1/ GM-Tg-equg-T65197-Ab-2 | Anti-Equine EPOR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T65197-Ab-1/ GM-Tg-hg-T65197-Ab-2; GM-Tg-rg-T65197-Ab-1/ GM-Tg-rg-T65197-Ab-2; GM-Tg-mg-T65197-Ab-1/ GM-Tg-mg-T65197-Ab-2; GM-Tg-cynog-T65197-Ab-1/ GM-Tg-cynog-T65197-Ab-2; GM-Tg-felg-T65197-Ab-1/ GM-Tg-felg-T65197-Ab-2; GM-Tg-cang-T65197-Ab-1/ GM-Tg-cang-T65197-Ab-2; GM-Tg-bovg-T65197-Ab-1/ GM-Tg-bovg-T65197-Ab-2; GM-Tg-equg-T65197-Ab-1/ GM-Tg-equg-T65197-Ab-2 |
| Products Name | Anti-EPOR monoclonal antibody |
| Format | mab |
| Target Name | EPOR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EPOR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-841 | |
| Biosimilar | GMP-Bios-INN-795 | Pre-Made Darbepoetin Alfa biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting EPOR |
| Biosimilar | GMP-Bios-INN-840 | Pre-Made Epoetin Alfa biosimilar, Recombinant Protein: Recombinant EPO(erythropoietin) therapeutic protein targeting EPOR Pre-made [INN Name] biosimilar, [Format] targeting [Target1/Target2]), recombinant [???] therapeutic protein targeting [alias1/Alias2] |
| Target Antigen | Products Developing | Multi-species EPOR/ EPO-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm001760 | mouse Epor Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001760 | mouse Epor Lentivirus particle |
Target information
| Target ID | GM-T65197 |
| Target Name | EPOR |
| Gene ID | 2057,13857,24336,714546,484943,101081364,281144,100057022 |
| Gene Symbol and Synonyms | EPO-R,EPOR |
| Uniprot Accession | P19235,Q07303,Q2KL21 |
| Uniprot Entry Name | EPOR_HUMAN,EPOR_RAT,EPOR_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000187266 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: EPOR, gene name: EPOR, also named as EPO-R. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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