EPOR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of EPOR. The page also collects GeneMedi's different modalities and formats products for EPOR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EPOR target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Pre-made EPOR-specific INN-index biosimilar (antibody&conjugates)-epoetin beta, darbepoetin alfa, epoetin alfa

Anti-EPOR therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Order
GMP-Bios-INN-841		epoetin beta		EPOR	pegylated
GMP-Bios-INN-795	Pre-Made Darbepoetin Alfa biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting EPOR	darbepoetin alfa		EPOR	Recombinant Protein
GMP-Bios-INN-840	Pre-Made Epoetin Alfa biosimilar, Recombinant Protein: Recombinant EPO(erythropoietin) therapeutic protein targeting EPOR Pre-made [INN Name] biosimilar, [Format] targeting [Target1/Target2]), recombinant [???] therapeutic protein targeting [alias1/Alias2]	epoetin alfa		EPOR	Recombinant Protein

Pre-made anti-EPOR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-EPOR benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EPOR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.	Antibody Name	Format	Classified by tag	Order
GM-Tg-hg-T65197-Ab	Anti-EPOR monoclonal antibody	mab	Biofunctional antibody, Therapeutics Target antibody