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Anti-HDAC1 monoclonal antibody
Pre-made anti-HDAC1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HDAC1/HDAC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T68547-Ab-1/ GM-Tg-hg-T68547-Ab-2 | Anti-Human HDAC1 monoclonal antibody | Human |
| GM-Tg-rg-T68547-Ab-1/ GM-Tg-rg-T68547-Ab-2 | Anti-Rat HDAC1 monoclonal antibody | Rat |
| GM-Tg-mg-T68547-Ab-1/ GM-Tg-mg-T68547-Ab-2 | Anti-Mouse HDAC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T68547-Ab-1/ GM-Tg-cynog-T68547-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HDAC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T68547-Ab-1/ GM-Tg-felg-T68547-Ab-2 | Anti-Feline HDAC1 monoclonal antibody | Feline |
| GM-Tg-cang-T68547-Ab-1/ GM-Tg-cang-T68547-Ab-2 | Anti-Canine HDAC1 monoclonal antibody | Canine |
| GM-Tg-bovg-T68547-Ab-1/ GM-Tg-bovg-T68547-Ab-2 | Anti-Bovine HDAC1 monoclonal antibody | Bovine |
| GM-Tg-equg-T68547-Ab-1/ GM-Tg-equg-T68547-Ab-2 | Anti-Equine HDAC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T68547-Ab-1/ GM-Tg-hg-T68547-Ab-2; GM-Tg-rg-T68547-Ab-1/ GM-Tg-rg-T68547-Ab-2; GM-Tg-mg-T68547-Ab-1/ GM-Tg-mg-T68547-Ab-2; GM-Tg-cynog-T68547-Ab-1/ GM-Tg-cynog-T68547-Ab-2; GM-Tg-felg-T68547-Ab-1/ GM-Tg-felg-T68547-Ab-2; GM-Tg-cang-T68547-Ab-1/ GM-Tg-cang-T68547-Ab-2; GM-Tg-bovg-T68547-Ab-1/ GM-Tg-bovg-T68547-Ab-2; GM-Tg-equg-T68547-Ab-1/ GM-Tg-equg-T68547-Ab-2 |
| Products Name | Anti-HDAC1 monoclonal antibody |
| Format | mab |
| Target Name | HDAC1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HDAC1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T68547-Ag-1 | Recombinant multi-species HDAC1/ GON-10/ HD1 protein |
| ORF Viral Vector | vGMLP000625 | human HDAC1 Lentivirus particle |
| ORF Viral Vector | pGMLP000625 | human HDAC1 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000603 | Norway rat Hdac1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001421 | mouse Hdac1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000603 | Norway rat Hdac1 Adenovirus particle |
| ORF Viral Vector | vGMLPm001421 | mouse Hdac1 Lentivirus particle |
Target information
| Target ID | GM-T68547 |
| Target Name | HDAC1 |
| Gene ID | 3065,433759,297893,708441,487309,101099228,404126,100070281 |
| Gene Symbol and Synonyms | GON-10,HD1,HDAC1,Hdac1-ps,KDAC1,MommeD5,RPD3,RPD3L1 |
| Uniprot Accession | Q13547,Q4QQW4,Q32PJ8 |
| Uniprot Entry Name | HDAC1_HUMAN,HDAC1_RAT,HDAC1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000116478 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HDAC1, gene name: HDAC1, also named as GON-10, HD1, RPD3, RPD3L1. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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