HDAC1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of HDAC1. The page also collects GeneMedi's different modalities and formats products for HDAC1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HDAC1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Target ID | GM-T68547 |
Target Name | HDAC1 |
Gene ID | 3065,433759,297893,708441,487309,101099228,404126,100070281 |
Gene Symbol and Synonyms | GON-10,HD1,HDAC1,Hdac1-ps,KDAC1,MommeD5,RPD3,RPD3L1 |
Uniprot Accession | Q13547,Q4QQW4,Q32PJ8 |
Uniprot Entry Name | HDAC1_HUMAN,HDAC1_RAT,HDAC1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000116478 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-HDAC1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-HDAC1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HDAC1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-HDAC1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species HDAC1/ GON-10/ HD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HDAC1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
HDAC1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made HDAC1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMLP000625 | human HDAC1 Lentivirus particle | NM_004964 | Human | Lentivirus particle | Detail |
pGMLP000625 | human HDAC1 Lentivirus plasmid | NM_004964 | Human | Lentivirus plasmid | Detail |
pGMAD000603 | Norway rat Hdac1 Adenovirus plasmid | NM_001025409.1 | Norway Rat | Adenovirus plasmid | Detail |
pGMLPm001421 | mouse Hdac1 Lentivirus plasmid | NM_008228.2 | Mouse | Lentivirus plasmid | Detail |
vGMAD000603 | Norway rat Hdac1 Adenovirus particle | NM_001025409.1 | Norway Rat | Adenovirus particle | Detail |
vGMLPm001421 | mouse Hdac1 Lentivirus particle | NM_008228.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.