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Anti-ESR2 monoclonal antibody
Pre-made anti-ESR2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ESR2/ESR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T80896-Ab-1/ GM-Tg-hg-T80896-Ab-2 | Anti-Human ESR2 monoclonal antibody | Human |
| GM-Tg-rg-T80896-Ab-1/ GM-Tg-rg-T80896-Ab-2 | Anti-Rat ESR2 monoclonal antibody | Rat |
| GM-Tg-mg-T80896-Ab-1/ GM-Tg-mg-T80896-Ab-2 | Anti-Mouse ESR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T80896-Ab-1/ GM-Tg-cynog-T80896-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ESR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T80896-Ab-1/ GM-Tg-felg-T80896-Ab-2 | Anti-Feline ESR2 monoclonal antibody | Feline |
| GM-Tg-cang-T80896-Ab-1/ GM-Tg-cang-T80896-Ab-2 | Anti-Canine ESR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T80896-Ab-1/ GM-Tg-bovg-T80896-Ab-2 | Anti-Bovine ESR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T80896-Ab-1/ GM-Tg-equg-T80896-Ab-2 | Anti-Equine ESR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T80896-Ab-1/ GM-Tg-hg-T80896-Ab-2; GM-Tg-rg-T80896-Ab-1/ GM-Tg-rg-T80896-Ab-2; GM-Tg-mg-T80896-Ab-1/ GM-Tg-mg-T80896-Ab-2; GM-Tg-cynog-T80896-Ab-1/ GM-Tg-cynog-T80896-Ab-2; GM-Tg-felg-T80896-Ab-1/ GM-Tg-felg-T80896-Ab-2; GM-Tg-cang-T80896-Ab-1/ GM-Tg-cang-T80896-Ab-2; GM-Tg-bovg-T80896-Ab-1/ GM-Tg-bovg-T80896-Ab-2; GM-Tg-equg-T80896-Ab-1/ GM-Tg-equg-T80896-Ab-2 |
| Products Name | Anti-ESR2 monoclonal antibody |
| Format | mab |
| Target Name | ESR2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ESR2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T80896-Ag-1 | Recombinant multi-species ESR2/ ER-BETA/ ESR-BETA protein |
| ORF Viral Vector | vGMLP001497 | human ESR2 Lentivirus particle |
| ORF Viral Vector | vGMLV000848 | human ESR2 Lentivirus particle |
| ORF Viral Vector | pGMLV000848 | human ESR2 Lentivirus plasmid |
| ORF Viral Vector | pGMLP001497 | human ESR2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005127 | mouse Esr2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005128 | mouse Esr2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005127 | mouse Esr2 Lentivirus particle |
| ORF Viral Vector | vGMLPm005128 | mouse Esr2 Lentivirus particle |
Target information
| Target ID | GM-T80896 |
| Target Name | ESR2 |
| Gene ID | 2100,13983,25149,574110,403639,101086317,281146,100033964 |
| Gene Symbol and Synonyms | er,ER-BETA,Erb,Erb2,ERbeta,ER[b],ESR-BETA,ESR2,ESRB,ESTRB,NR3A2,ODG8 |
| Uniprot Accession | Q92731,Q62986,Q9TTE5,Q9XSB5 |
| Uniprot Entry Name | ESR2_HUMAN,ESR2_MACMU,ESR2_RAT,ESR2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000140009 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ESR2, gene name: ESR2, also named as ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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