- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-INS/ IDDM/ IDDM1 functional antibody
Anti-INS/ IDDM/ IDDM1 functional antibody for cell culture, ELISA & in-vivo assay
Go to INS/INS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T82841-Ab-1/ GM-Tg-hg-T82841-Ab-2 | Anti-Human INS monoclonal antibody | Human |
| GM-Tg-rg-T82841-Ab-1/ GM-Tg-rg-T82841-Ab-2 | Anti-Rat INS monoclonal antibody | Rat |
| GM-Tg-mg-T82841-Ab-1/ GM-Tg-mg-T82841-Ab-2 | Anti-Mouse INS monoclonal antibody | Mouse |
| GM-Tg-cynog-T82841-Ab-1/ GM-Tg-cynog-T82841-Ab-2 | Anti-Cynomolgus/ Rhesus macaque INS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T82841-Ab-1/ GM-Tg-felg-T82841-Ab-2 | Anti-Feline INS monoclonal antibody | Feline |
| GM-Tg-cang-T82841-Ab-1/ GM-Tg-cang-T82841-Ab-2 | Anti-Canine INS monoclonal antibody | Canine |
| GM-Tg-bovg-T82841-Ab-1/ GM-Tg-bovg-T82841-Ab-2 | Anti-Bovine INS monoclonal antibody | Bovine |
| GM-Tg-equg-T82841-Ab-1/ GM-Tg-equg-T82841-Ab-2 | Anti-Equine INS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T82841-Ab-1/ GM-Tg-hg-T82841-Ab-2; GM-Tg-rg-T82841-Ab-1/ GM-Tg-rg-T82841-Ab-2; GM-Tg-mg-T82841-Ab-1/ GM-Tg-mg-T82841-Ab-2; GM-Tg-cynog-T82841-Ab-1/ GM-Tg-cynog-T82841-Ab-2; GM-Tg-felg-T82841-Ab-1/ GM-Tg-felg-T82841-Ab-2; GM-Tg-cang-T82841-Ab-1/ GM-Tg-cang-T82841-Ab-2; GM-Tg-bovg-T82841-Ab-1/ GM-Tg-bovg-T82841-Ab-2; GM-Tg-equg-T82841-Ab-1/ GM-Tg-equg-T82841-Ab-2 |
| Products Name | Anti-INS monoclonal antibody |
| Format | mab |
| Target Name | INS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-INS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T82841-Ag-1 | Recombinant multi-species INS/ IDDM/ IDDM1 protein |
| ORF Viral Vector | vGMAP000054 | Human INS Adenovirus particle |
| ORF Viral Vector | pGMAP000054 | Human INS Adenovirus plasmid |
Target information
| Target ID | GM-T82841 |
| Target Name | INS |
| Gene ID | 3630,16334,24506,704534,483665,493804,280829,111776000 |
| Gene Symbol and Synonyms | CP-II,IDDM,IDDM1,IDDM2,ILPR,INS,Ins-2,Ins2,InsII,IRDN,Mody,MODY10,Mody4,PNDM4 |
| Uniprot Accession | P01308,P01323,P01321,P06306,P01317,P01310 |
| Uniprot Entry Name | INS_HUMAN,INS2_RAT,INS_FELCA,INS_CANLF,INS_BOVIN,INS_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000254647 |
| Target Classification | N/A |
The target: INS, gene name: INS, also named as IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
