Anti-TRPV1/ VR1 monoclonal antibody

Anti-TRPV1/ VR1 antibody for FACS & in-vivo assay

Target products collectionGo to TRPV1/TRPV1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83193-Ab-1/ GM-Tg-hg-T83193-Ab-2Anti-Human TRPV1 monoclonal antibodyHuman
GM-Tg-rg-T83193-Ab-1/ GM-Tg-rg-T83193-Ab-2Anti-Rat TRPV1 monoclonal antibodyRat
GM-Tg-mg-T83193-Ab-1/ GM-Tg-mg-T83193-Ab-2Anti-Mouse TRPV1 monoclonal antibodyMouse
GM-Tg-cynog-T83193-Ab-1/ GM-Tg-cynog-T83193-Ab-2Anti-Cynomolgus/ Rhesus macaque TRPV1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83193-Ab-1/ GM-Tg-felg-T83193-Ab-2Anti-Feline TRPV1 monoclonal antibodyFeline
GM-Tg-cang-T83193-Ab-1/ GM-Tg-cang-T83193-Ab-2Anti-Canine TRPV1 monoclonal antibodyCanine
GM-Tg-bovg-T83193-Ab-1/ GM-Tg-bovg-T83193-Ab-2Anti-Bovine TRPV1 monoclonal antibodyBovine
GM-Tg-equg-T83193-Ab-1/ GM-Tg-equg-T83193-Ab-2Anti-Equine TRPV1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83193-Ab-1/ GM-Tg-hg-T83193-Ab-2; GM-Tg-rg-T83193-Ab-1/ GM-Tg-rg-T83193-Ab-2;
GM-Tg-mg-T83193-Ab-1/ GM-Tg-mg-T83193-Ab-2; GM-Tg-cynog-T83193-Ab-1/ GM-Tg-cynog-T83193-Ab-2;
GM-Tg-felg-T83193-Ab-1/ GM-Tg-felg-T83193-Ab-2; GM-Tg-cang-T83193-Ab-1/ GM-Tg-cang-T83193-Ab-2;
GM-Tg-bovg-T83193-Ab-1/ GM-Tg-bovg-T83193-Ab-2; GM-Tg-equg-T83193-Ab-1/ GM-Tg-equg-T83193-Ab-2
Products NameAnti-TRPV1 monoclonal antibody
Formatmab
Target NameTRPV1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TRPV1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TRPV1/ VR1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000632human TRPV1 Lentivirus particle
    ORF Viral VectorpGMLV000632human TRPV1 Lentivirus plasmid
    ORF Viral VectorvGMLP002884human TRPV1 Lentivirus particle
    ORF Viral VectorpGMLP002884human TRPV1 Lentivirus plasmid
    ORF Viral VectorpGMLV000436mouse Trpv1 Lentivirus plasmid
    ORF Viral VectorpGMAD000590house mouse Trpv1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000088rat Trpv1 AAV plasmid
    ORF Viral VectorvGMLV000436mouse Trpv1 Lentivirus particle
    ORF Viral VectorvGMAD000590house mouse Trpv1 Adenovirus particle
    ORF Viral VectorvGMAAV000088rat Trpv1 AAV particle


    Target information

    Target IDGM-T83193
    Target NameTRPV1
    Gene ID7442,193034,83810,721455,445457,101093406,107131508,100034158
    Gene Symbol and SynonymsOTRPC1,TRPV1,TRPV1alpha,TRPV1beta,TRPV1_SON,VR-1,VR.5'sv,VR1,Vr1l1
    Uniprot AccessionQ8NER1,O35433,Q697L1
    Uniprot Entry NameTRPV1_HUMAN,TRPV1_RAT,TRPV1_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000196689
    Target ClassificationIon Channel

    The target: TRPV1, gene name: TRPV1, also named as VR1. Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.