Anti-TRPV1/ VR1 monoclonal antibody
Anti-TRPV1/ VR1 antibody for FACS & in-vivo assay
Go to TRPV1/TRPV1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T83193-Ab-1/ GM-Tg-hg-T83193-Ab-2 | Anti-Human TRPV1 monoclonal antibody | Human |
GM-Tg-rg-T83193-Ab-1/ GM-Tg-rg-T83193-Ab-2 | Anti-Rat TRPV1 monoclonal antibody | Rat |
GM-Tg-mg-T83193-Ab-1/ GM-Tg-mg-T83193-Ab-2 | Anti-Mouse TRPV1 monoclonal antibody | Mouse |
GM-Tg-cynog-T83193-Ab-1/ GM-Tg-cynog-T83193-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TRPV1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T83193-Ab-1/ GM-Tg-felg-T83193-Ab-2 | Anti-Feline TRPV1 monoclonal antibody | Feline |
GM-Tg-cang-T83193-Ab-1/ GM-Tg-cang-T83193-Ab-2 | Anti-Canine TRPV1 monoclonal antibody | Canine |
GM-Tg-bovg-T83193-Ab-1/ GM-Tg-bovg-T83193-Ab-2 | Anti-Bovine TRPV1 monoclonal antibody | Bovine |
GM-Tg-equg-T83193-Ab-1/ GM-Tg-equg-T83193-Ab-2 | Anti-Equine TRPV1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T83193-Ab-1/ GM-Tg-hg-T83193-Ab-2; GM-Tg-rg-T83193-Ab-1/ GM-Tg-rg-T83193-Ab-2; GM-Tg-mg-T83193-Ab-1/ GM-Tg-mg-T83193-Ab-2; GM-Tg-cynog-T83193-Ab-1/ GM-Tg-cynog-T83193-Ab-2; GM-Tg-felg-T83193-Ab-1/ GM-Tg-felg-T83193-Ab-2; GM-Tg-cang-T83193-Ab-1/ GM-Tg-cang-T83193-Ab-2; GM-Tg-bovg-T83193-Ab-1/ GM-Tg-bovg-T83193-Ab-2; GM-Tg-equg-T83193-Ab-1/ GM-Tg-equg-T83193-Ab-2 |
Products Name | Anti-TRPV1 monoclonal antibody |
Format | mab |
Target Name | TRPV1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-TRPV1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species TRPV1/ VR1 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLV000632 | human TRPV1 Lentivirus particle |
ORF Viral Vector | pGMLV000632 | human TRPV1 Lentivirus plasmid |
ORF Viral Vector | vGMLP002884 | human TRPV1 Lentivirus particle |
ORF Viral Vector | pGMLP002884 | human TRPV1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000436 | mouse Trpv1 Lentivirus plasmid |
ORF Viral Vector | pGMAD000590 | house mouse Trpv1 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000088 | rat Trpv1 AAV plasmid |
ORF Viral Vector | vGMLV000436 | mouse Trpv1 Lentivirus particle |
ORF Viral Vector | vGMAD000590 | house mouse Trpv1 Adenovirus particle |
ORF Viral Vector | vGMAAV000088 | rat Trpv1 AAV particle |
Target information
Target ID | GM-T83193 |
Target Name | TRPV1 |
Gene ID | 7442,193034,83810,721455,445457,101093406,107131508,100034158 |
Gene Symbol and Synonyms | OTRPC1,TRPV1,TRPV1alpha,TRPV1beta,TRPV1_SON,VR-1,VR.5'sv,VR1,Vr1l1 |
Uniprot Accession | Q8NER1,O35433,Q697L1 |
Uniprot Entry Name | TRPV1_HUMAN,TRPV1_RAT,TRPV1_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000196689 |
Target Classification | Ion Channel |
The target: TRPV1, gene name: TRPV1, also named as VR1. Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.