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Anti-CBS monoclonal antibody
Pre-made anti-CBS monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CBS/CBS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85309-Ab-1/ GM-Tg-hg-T85309-Ab-2 | Anti-Human CBS monoclonal antibody | Human |
| GM-Tg-rg-T85309-Ab-1/ GM-Tg-rg-T85309-Ab-2 | Anti-Rat CBS monoclonal antibody | Rat |
| GM-Tg-mg-T85309-Ab-1/ GM-Tg-mg-T85309-Ab-2 | Anti-Mouse CBS monoclonal antibody | Mouse |
| GM-Tg-cynog-T85309-Ab-1/ GM-Tg-cynog-T85309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CBS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85309-Ab-1/ GM-Tg-felg-T85309-Ab-2 | Anti-Feline CBS monoclonal antibody | Feline |
| GM-Tg-cang-T85309-Ab-1/ GM-Tg-cang-T85309-Ab-2 | Anti-Canine CBS monoclonal antibody | Canine |
| GM-Tg-bovg-T85309-Ab-1/ GM-Tg-bovg-T85309-Ab-2 | Anti-Bovine CBS monoclonal antibody | Bovine |
| GM-Tg-equg-T85309-Ab-1/ GM-Tg-equg-T85309-Ab-2 | Anti-Equine CBS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85309-Ab-1/ GM-Tg-hg-T85309-Ab-2; GM-Tg-rg-T85309-Ab-1/ GM-Tg-rg-T85309-Ab-2; GM-Tg-mg-T85309-Ab-1/ GM-Tg-mg-T85309-Ab-2; GM-Tg-cynog-T85309-Ab-1/ GM-Tg-cynog-T85309-Ab-2; GM-Tg-felg-T85309-Ab-1/ GM-Tg-felg-T85309-Ab-2; GM-Tg-cang-T85309-Ab-1/ GM-Tg-cang-T85309-Ab-2; GM-Tg-bovg-T85309-Ab-1/ GM-Tg-bovg-T85309-Ab-2; GM-Tg-equg-T85309-Ab-1/ GM-Tg-equg-T85309-Ab-2 |
| Products Name | Anti-CBS monoclonal antibody |
| Format | mab |
| Target Name | CBS |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CBS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T85309-Ag-1 | Recombinant multi-species CBS/ CBSL/ HIP4 protein |
| ORF Viral Vector | pGMLP003973 | human CBS Lentivirus plasmid |
| ORF Viral Vector | pGMAP000387 | Human CBS Adenovirus plasmid |
| ORF Viral Vector | vGMLP003973 | human CBS Lentivirus particle |
| ORF Viral Vector | vGMAP000526 | Human CBS Adenovirus particle |
| ORF Viral Vector | vGMAP000387 | Human CBS Adenovirus particle |
| ORF Viral Vector | vGMAP000190 | Human CBS Adenovirus particle |
| ORF Viral Vector | pGMAP000190 | Human CBS Adenovirus plasmid |
| ORF Viral Vector | pGMAP000526 | Human CBS Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002688 | mouse Cbs Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002688 | mouse Cbs Lentivirus particle |
Target information
| Target ID | GM-T85309 |
| Target Name | CBS |
| Gene ID | 875,12411,24250,100423684,611071,101093038,514525 |
| Gene Symbol and Synonyms | CBS,CBSL,HIP4 |
| Uniprot Accession | P35520,P32232 |
| Uniprot Entry Name | CBS_HUMAN,CBS_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000160200 |
| Target Classification | N/A |
The target: CBS, gene name: CBS, also named as CBSL, HIP4. The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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