CBS: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of CBS. The page also collects GeneMedi's different modalities and formats products for CBS in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CBS target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Target ID | GM-T85309 |
Target Name | CBS |
Gene ID | 875,12411,24250,100423684,611071,101093038,514525 |
Gene Symbol and Synonyms | CBS,CBSL,HIP4 |
Uniprot Accession | P35520,P32232 |
Uniprot Entry Name | CBS_HUMAN,CBS_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Diagnostics Biomarker |
Disease | N/A |
Gene Ensembl | ENSG00000160200 |
Target Classification | N/A |
Pre-made anti-CBS inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-CBS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CBS mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-CBS monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
Recombinant multi-species CBS/ CBSL/ HIP4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CBS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
CBS protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made CBS viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLP003973 | human CBS Lentivirus plasmid | NM_001178009.2 | Human | Lentivirus plasmid | Detail |
pGMAP000387 | Human CBS Adenovirus plasmid | BC007257 | Human | Adenovirus plasmid | Detail |
vGMLP003973 | human CBS Lentivirus particle | NM_001178009.2 | Human | Lentivirus particle | Detail |
vGMAP000526 | Human CBS Adenovirus particle | BC007257 | Human | Adenovirus particle | Detail |
vGMAP000387 | Human CBS Adenovirus particle | BC007257 | Human | Adenovirus particle | Detail |
vGMAP000190 | Human CBS Adenovirus particle | BC007257 | Human | Adenovirus particle | Detail |
pGMAP000190 | Human CBS Adenovirus plasmid | BC007257 | Human | Adenovirus plasmid | Detail |
pGMAP000526 | Human CBS Adenovirus plasmid | BC007257 | Human | Adenovirus plasmid | Detail |
pGMLPm002688 | mouse Cbs Lentivirus plasmid | NM_144855 | Mouse | Lentivirus plasmid | Detail |
vGMLPm002688 | mouse Cbs Lentivirus particle | NM_144855 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.