Anti-TTHY/ TTR/ ATTR functional antibody
Anti-TTHY/ TTR/ ATTR functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T86462-Ab-1/ GM-Tg-hg-T86462-Ab-2 | Anti-Human TTR monoclonal antibody | Human |
GM-Tg-rg-T86462-Ab-1/ GM-Tg-rg-T86462-Ab-2 | Anti-Rat TTR monoclonal antibody | Rat |
GM-Tg-mg-T86462-Ab-1/ GM-Tg-mg-T86462-Ab-2 | Anti-Mouse TTR monoclonal antibody | Mouse |
GM-Tg-cynog-T86462-Ab-1/ GM-Tg-cynog-T86462-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TTR monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T86462-Ab-1/ GM-Tg-felg-T86462-Ab-2 | Anti-Feline TTR monoclonal antibody | Feline |
GM-Tg-cang-T86462-Ab-1/ GM-Tg-cang-T86462-Ab-2 | Anti-Canine TTR monoclonal antibody | Canine |
GM-Tg-bovg-T86462-Ab-1/ GM-Tg-bovg-T86462-Ab-2 | Anti-Bovine TTR monoclonal antibody | Bovine |
GM-Tg-equg-T86462-Ab-1/ GM-Tg-equg-T86462-Ab-2 | Anti-Equine TTR monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T86462-Ab-1/ GM-Tg-hg-T86462-Ab-2; GM-Tg-rg-T86462-Ab-1/ GM-Tg-rg-T86462-Ab-2; GM-Tg-mg-T86462-Ab-1/ GM-Tg-mg-T86462-Ab-2; GM-Tg-cynog-T86462-Ab-1/ GM-Tg-cynog-T86462-Ab-2; GM-Tg-felg-T86462-Ab-1/ GM-Tg-felg-T86462-Ab-2; GM-Tg-cang-T86462-Ab-1/ GM-Tg-cang-T86462-Ab-2; GM-Tg-bovg-T86462-Ab-1/ GM-Tg-bovg-T86462-Ab-2; GM-Tg-equg-T86462-Ab-1/ GM-Tg-equg-T86462-Ab-2 |
Products Name | Anti-TTR monoclonal antibody |
Format | mab |
Target Name | TTR |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-TTR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T86462-Ag-1 | Recombinant multi-species TTHY/ TTR/ ATTR protein |
ORF Viral Vector | pGMAP000187 | Human TTR Adenovirus plasmid |
ORF Viral Vector | vGMLP002013 | human TTR Lentivirus particle |
ORF Viral Vector | vGMAP000187 | Human TTR Adenovirus particle |
ORF Viral Vector | vGMLP000332 | human TTR Lentivirus particle |
ORF Viral Vector | pGMLP002013 | human TTR Lentivirus plasmid |
ORF Viral Vector | pGMLP000332 | human TTR Lentivirus plasmid |
ORF Viral Vector | pGMLPm000227 | mouse Ttr Lentivirus plasmid |
ORF Viral Vector | vGMLPm000227 | mouse Ttr Lentivirus particle |
Target information
Target ID | GM-T86462 |
Target Name | TTR |
Gene ID | 7276,22139,24856,705943,480167,101085927,280948,100052147 |
Gene Symbol and Synonyms | ATTR,CTS,CTS1,HEL111,HsT2651,Lr1,PALB,prealbumin,TBPA,TT,TTN,TTR,TTR1 |
Uniprot Accession | P02766,P02767,O46375 |
Uniprot Entry Name | TTHY_HUMAN,TTHY_RAT,TTHY_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | Ovary Cancer, hepatitis B, ovarian cancer, Ovarian Cancer, Diabetic Nephropathy, Alzheimer's Disease, Choroid plexus tumors, Dent disease, IgA glomerulonephritis, Nephrotic syndrome with focal and segmental glomerular lesions, Type 2 diabetes mellitus |
Gene Ensembl | ENSG00000118271 |
Target Classification | N/A |
The target: TTR, gene name: TTR, also named as ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA. This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.