Recombinant multi-species TTHY/ TTR/ ATTR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TTR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: TTR, gene name: TTR, also named as ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA. This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T86462-Ag-1	Human TTR protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T86462-Ag-1	Rat TTR protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T86462-Ag-1	Mouse TTR protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T86462-Ag-1	Cynomolgus/ Rhesus macaque TTR protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T86462-Ag-1	Feline TTR protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T86462-Ag-1	Canine TTR protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T86462-Ag-1	Bovine TTR protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T86462-Ag-1	Equine TTR protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T86462-Ag, GM-Tg-rg-T86462-Ag, GM-Tg-mg-T86462-Ag, GM-Tg-cynog-T86462-Ag, GM-Tg-felg-T86462-Ag, GM-Tg-cang-T86462-Ag, GM-Tg-bovg-T86462-Ag, GM-Tg-equg-T86462-Ag-1
Products Name	TTR protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	TTR
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TTR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.