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Anti-FDPS monoclonal antibody
Pre-made anti-FDPS monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FDPS/FDPS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T86528-Ab-1/ GM-Tg-hg-T86528-Ab-2 | Anti-Human FDPS monoclonal antibody | Human |
| GM-Tg-rg-T86528-Ab-1/ GM-Tg-rg-T86528-Ab-2 | Anti-Rat FDPS monoclonal antibody | Rat |
| GM-Tg-mg-T86528-Ab-1/ GM-Tg-mg-T86528-Ab-2 | Anti-Mouse FDPS monoclonal antibody | Mouse |
| GM-Tg-cynog-T86528-Ab-1/ GM-Tg-cynog-T86528-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FDPS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T86528-Ab-1/ GM-Tg-felg-T86528-Ab-2 | Anti-Feline FDPS monoclonal antibody | Feline |
| GM-Tg-cang-T86528-Ab-1/ GM-Tg-cang-T86528-Ab-2 | Anti-Canine FDPS monoclonal antibody | Canine |
| GM-Tg-bovg-T86528-Ab-1/ GM-Tg-bovg-T86528-Ab-2 | Anti-Bovine FDPS monoclonal antibody | Bovine |
| GM-Tg-equg-T86528-Ab-1/ GM-Tg-equg-T86528-Ab-2 | Anti-Equine FDPS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T86528-Ab-1/ GM-Tg-hg-T86528-Ab-2; GM-Tg-rg-T86528-Ab-1/ GM-Tg-rg-T86528-Ab-2; GM-Tg-mg-T86528-Ab-1/ GM-Tg-mg-T86528-Ab-2; GM-Tg-cynog-T86528-Ab-1/ GM-Tg-cynog-T86528-Ab-2; GM-Tg-felg-T86528-Ab-1/ GM-Tg-felg-T86528-Ab-2; GM-Tg-cang-T86528-Ab-1/ GM-Tg-cang-T86528-Ab-2; GM-Tg-bovg-T86528-Ab-1/ GM-Tg-bovg-T86528-Ab-2; GM-Tg-equg-T86528-Ab-1/ GM-Tg-equg-T86528-Ab-2 |
| Products Name | Anti-FDPS monoclonal antibody |
| Format | mab |
| Target Name | FDPS |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FDPS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T86528-Ag-1 | Recombinant multi-species FPPS/ FDPS/ FPS protein |
| ORF Viral Vector | pGMLP000619 | human FDPS Lentivirus plasmid |
| ORF Viral Vector | vGMLP000619 | human FDPS Lentivirus particle |
| ORF Viral Vector | pGMLPm002074 | mouse Fdps Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002074 | mouse Fdps Lentivirus particle |
Target information
| Target ID | GM-T86528 |
| Target Name | FDPS |
| Gene ID | 2224,110196,83791,717761,480129,101086533,281156,100063641 |
| Gene Symbol and Synonyms | 6030492I17Rik,Ac2-125,FDPS,Fdpsl1,FPPS,FPS,mKIAA1293,POROK9 |
| Uniprot Accession | P14324,P05369,Q8WMY2 |
| Uniprot Entry Name | FPPS_HUMAN,FPPS_RAT,FPPS_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000160752 |
| Target Classification | N/A |
The target: FDPS, gene name: FDPS, also named as FPPS, FPS, POROK9. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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