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Anti-CDK6 monoclonal antibody
Pre-made anti-CDK6 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CDK6/CDK6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T89361-Ab-1/ GM-Tg-hg-T89361-Ab-2 | Anti-Human CDK6 monoclonal antibody | Human |
| GM-Tg-rg-T89361-Ab-1/ GM-Tg-rg-T89361-Ab-2 | Anti-Rat CDK6 monoclonal antibody | Rat |
| GM-Tg-mg-T89361-Ab-1/ GM-Tg-mg-T89361-Ab-2 | Anti-Mouse CDK6 monoclonal antibody | Mouse |
| GM-Tg-cynog-T89361-Ab-1/ GM-Tg-cynog-T89361-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDK6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T89361-Ab-1/ GM-Tg-felg-T89361-Ab-2 | Anti-Feline CDK6 monoclonal antibody | Feline |
| GM-Tg-cang-T89361-Ab-1/ GM-Tg-cang-T89361-Ab-2 | Anti-Canine CDK6 monoclonal antibody | Canine |
| GM-Tg-bovg-T89361-Ab-1/ GM-Tg-bovg-T89361-Ab-2 | Anti-Bovine CDK6 monoclonal antibody | Bovine |
| GM-Tg-equg-T89361-Ab-1/ GM-Tg-equg-T89361-Ab-2 | Anti-Equine CDK6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T89361-Ab-1/ GM-Tg-hg-T89361-Ab-2; GM-Tg-rg-T89361-Ab-1/ GM-Tg-rg-T89361-Ab-2; GM-Tg-mg-T89361-Ab-1/ GM-Tg-mg-T89361-Ab-2; GM-Tg-cynog-T89361-Ab-1/ GM-Tg-cynog-T89361-Ab-2; GM-Tg-felg-T89361-Ab-1/ GM-Tg-felg-T89361-Ab-2; GM-Tg-cang-T89361-Ab-1/ GM-Tg-cang-T89361-Ab-2; GM-Tg-bovg-T89361-Ab-1/ GM-Tg-bovg-T89361-Ab-2; GM-Tg-equg-T89361-Ab-1/ GM-Tg-equg-T89361-Ab-2 |
| Products Name | Anti-CDK6 monoclonal antibody |
| Format | mab |
| Target Name | CDK6 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CDK6 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T89361-Ag-1 | Recombinant multi-species CDK6/ MCPH12/ PLSTIRE protein |
| ORF Viral Vector | vGMLP000458 | human CDK6 Lentivirus particle |
| ORF Viral Vector | pGMAP000280 | Human CDK6 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000280 | Human CDK6 Adenovirus particle |
| ORF Viral Vector | pGMLP000458 | human CDK6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000351 | mouse Cdk6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000351 | mouse Cdk6 Lentivirus particle |
Target information
| Target ID | GM-T89361 |
| Target Name | CDK6 |
| Gene ID | 1021,12571,114483,701822,609920,100037415,511754,100061625 |
| Gene Symbol and Synonyms | CDK6,Crk2,MCPH12,PLSTIRE |
| Uniprot Accession | Q00534 |
| Uniprot Entry Name | CDK6_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | breast tumor |
| Gene Ensembl | ENSG00000105810 |
| Target Classification | Kinase |
The target: CDK6, gene name: CDK6, also named as MCPH12, PLSTIRE. The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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