Recombinant multi-species CDK6/ MCPH12/ PLSTIRE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CDK6, gene name: CDK6, also named as MCPH12, PLSTIRE. The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T89361-Ag-1	Human CDK6 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T89361-Ag-1	Rat CDK6 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T89361-Ag-1	Mouse CDK6 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T89361-Ag-1	Cynomolgus/ Rhesus macaque CDK6 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T89361-Ag-1	Feline CDK6 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T89361-Ag-1	Canine CDK6 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T89361-Ag-1	Bovine CDK6 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T89361-Ag-1	Equine CDK6 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T89361-Ag, GM-Tg-rg-T89361-Ag, GM-Tg-mg-T89361-Ag, GM-Tg-cynog-T89361-Ag, GM-Tg-felg-T89361-Ag, GM-Tg-cang-T89361-Ag, GM-Tg-bovg-T89361-Ag, GM-Tg-equg-T89361-Ag-1
Products Name	CDK6 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CDK6
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.