Anti-ESR monoclonal antibody
Pre-made anti-ESR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T89534-Ab-1/ GM-Tg-hg-T89534-Ab-2 | Anti-Human ESR/ESR1 monoclonal antibody | Human |
GM-Tg-rg-T89534-Ab-1/ GM-Tg-rg-T89534-Ab-2 | Anti-Rat ESR/ESR1 monoclonal antibody | Rat |
GM-Tg-mg-T89534-Ab-1/ GM-Tg-mg-T89534-Ab-2 | Anti-Mouse ESR/ESR1 monoclonal antibody | Mouse |
GM-Tg-cynog-T89534-Ab-1/ GM-Tg-cynog-T89534-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ESR/ESR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T89534-Ab-1/ GM-Tg-felg-T89534-Ab-2 | Anti-Feline ESR/ESR1 monoclonal antibody | Feline |
GM-Tg-cang-T89534-Ab-1/ GM-Tg-cang-T89534-Ab-2 | Anti-Canine ESR/ESR1 monoclonal antibody | Canine |
GM-Tg-bovg-T89534-Ab-1/ GM-Tg-bovg-T89534-Ab-2 | Anti-Bovine ESR/ESR1 monoclonal antibody | Bovine |
GM-Tg-equg-T89534-Ab-1/ GM-Tg-equg-T89534-Ab-2 | Anti-Equine ESR/ESR1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T89534-Ab-1/ GM-Tg-hg-T89534-Ab-2; GM-Tg-rg-T89534-Ab-1/ GM-Tg-rg-T89534-Ab-2; GM-Tg-mg-T89534-Ab-1/ GM-Tg-mg-T89534-Ab-2; GM-Tg-cynog-T89534-Ab-1/ GM-Tg-cynog-T89534-Ab-2; GM-Tg-felg-T89534-Ab-1/ GM-Tg-felg-T89534-Ab-2; GM-Tg-cang-T89534-Ab-1/ GM-Tg-cang-T89534-Ab-2; GM-Tg-bovg-T89534-Ab-1/ GM-Tg-bovg-T89534-Ab-2; GM-Tg-equg-T89534-Ab-1/ GM-Tg-equg-T89534-Ab-2 |
Products Name | Anti-ESR/ESR1 monoclonal antibody |
Format | mab |
Target Name | ESR |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-ESR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T89534-Ag-1 | Recombinant multi-species ESR1/ ESR/ ER protein |
ORF Viral Vector | vGMAP000547 | Human ESR1 Adenovirus particle |
ORF Viral Vector | pGMAP000547 | Human ESR1 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000280 | Norway rat Esr1 AAV plasmid |
ORF Viral Vector | pGMLPm004835 | mouse Esr1 Lentivirus plasmid |
ORF Viral Vector | vGMAAV000280 | Norway rat Esr1 AAV particle |
ORF Viral Vector | vGMLPm004835 | mouse Esr1 Lentivirus particle |
Target information
Target ID | GM-T89534 |
Target Name | ESR |
Gene ID | 2099,13982,24890,613025,403640,552888,407238,791249 |
Gene Symbol and Synonyms | ER,ER-alpha,Era,ERalpha,ESR,ESR1,ESRA,Estr,Estra,ESTRR,NR3A1,RNESTROR |
Uniprot Accession | P03372,P06211,P49886,Q53AD2,P49884,Q9TV98 |
Uniprot Entry Name | ESR1_HUMAN,ESR1_MACMU,ESR1_RAT,ESR1_FELCA,ESR1_BOVIN,ESR1_HORSE |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Breast Cancer |
Gene Ensembl | ENSG00000091831 |
Target Classification | Nuclear Receptors |
The target: ESR, gene name: ESR1, also named as ER, ESR, ESRA, ESTRR, Era, NR3A1. This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.