Anti-CSF3R/ G-CSF-R/ CD114 monoclonal antibody
Anti-CSF3R/ G-CSF-R/ CD114 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T98913-Ab-1/ GM-Tg-hg-T98913-Ab-2 | Anti-Human G-CSF-R/CSF3R monoclonal antibody | Human |
GM-Tg-rg-T98913-Ab-1/ GM-Tg-rg-T98913-Ab-2 | Anti-Rat G-CSF-R/CSF3R monoclonal antibody | Rat |
GM-Tg-mg-T98913-Ab-1/ GM-Tg-mg-T98913-Ab-2 | Anti-Mouse G-CSF-R/CSF3R monoclonal antibody | Mouse |
GM-Tg-cynog-T98913-Ab-1/ GM-Tg-cynog-T98913-Ab-2 | Anti-Cynomolgus/ Rhesus macaque G-CSF-R/CSF3R monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T98913-Ab-1/ GM-Tg-felg-T98913-Ab-2 | Anti-Feline G-CSF-R/CSF3R monoclonal antibody | Feline |
GM-Tg-cang-T98913-Ab-1/ GM-Tg-cang-T98913-Ab-2 | Anti-Canine G-CSF-R/CSF3R monoclonal antibody | Canine |
GM-Tg-bovg-T98913-Ab-1/ GM-Tg-bovg-T98913-Ab-2 | Anti-Bovine G-CSF-R/CSF3R monoclonal antibody | Bovine |
GM-Tg-equg-T98913-Ab-1/ GM-Tg-equg-T98913-Ab-2 | Anti-Equine G-CSF-R/CSF3R monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T98913-Ab-1/ GM-Tg-hg-T98913-Ab-2; GM-Tg-rg-T98913-Ab-1/ GM-Tg-rg-T98913-Ab-2; GM-Tg-mg-T98913-Ab-1/ GM-Tg-mg-T98913-Ab-2; GM-Tg-cynog-T98913-Ab-1/ GM-Tg-cynog-T98913-Ab-2; GM-Tg-felg-T98913-Ab-1/ GM-Tg-felg-T98913-Ab-2; GM-Tg-cang-T98913-Ab-1/ GM-Tg-cang-T98913-Ab-2; GM-Tg-bovg-T98913-Ab-1/ GM-Tg-bovg-T98913-Ab-2; GM-Tg-equg-T98913-Ab-1/ GM-Tg-equg-T98913-Ab-2 |
Products Name | Anti-G-CSF-R/CSF3R monoclonal antibody |
Format | mab |
Target Name | G-CSF-R |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-G-CSF-R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-818 | |
Biosimilar | GMP-Bios-INN-812 | Pre-Made Efbemalenograstim Alfa Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7 |
Biosimilar | GMP-Bios-INN-852 | Pre-Made Filgrastim Biosimilar, Recombinant Protein targeting CSF3R: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7 |
Biosimilar | GMP-Bios-INN-748 | Pre-Made Balugrastim Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with ALB (albumin, human serum albumin, HSA): Recombinant therapeutic protein targeting CD114/GCSFR/SCN7 |
Biosimilar | GMP-Bios-ab-655 | Pre-Made Anumigilimab biosimilar, Whole mAb, Anti-CSF3R/G-CSF-R Antibody: Anti-CD114/GCSFR/SCN7 therapeutic antibody |
Biosimilar | GMP-Bios-INN-951 | |
Target Antigen | Products Developing | Multi-species CSF3R/ G-CSF-R/ CD114 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T98913 |
Target Name | G-CSF-R |
Gene ID | 1441,12986,298518,713485,607605,101089787,100069253 |
Gene Symbol and Synonyms | CD114,CSF3R,Csfgr,G-CSF-R,G-CSFR,GCSFR,SCN7 |
Uniprot Accession | Q99062 |
Uniprot Entry Name | CSF3R_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000119535 |
Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: G-CSF-R, gene name: CSF3R, also named as CD114, GCSFR, SCN7. The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.