Anti-CSF3R/ G-CSF-R/ CD114 monoclonal antibody

Anti-CSF3R/ G-CSF-R/ CD114 antibody for FACS & in-vivo assay

Target products collectionGo to G-CSF-R/CSF3R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T98913-Ab-1/ GM-Tg-hg-T98913-Ab-2Anti-Human G-CSF-R/CSF3R monoclonal antibodyHuman
GM-Tg-rg-T98913-Ab-1/ GM-Tg-rg-T98913-Ab-2Anti-Rat G-CSF-R/CSF3R monoclonal antibodyRat
GM-Tg-mg-T98913-Ab-1/ GM-Tg-mg-T98913-Ab-2Anti-Mouse G-CSF-R/CSF3R monoclonal antibodyMouse
GM-Tg-cynog-T98913-Ab-1/ GM-Tg-cynog-T98913-Ab-2Anti-Cynomolgus/ Rhesus macaque G-CSF-R/CSF3R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T98913-Ab-1/ GM-Tg-felg-T98913-Ab-2Anti-Feline G-CSF-R/CSF3R monoclonal antibodyFeline
GM-Tg-cang-T98913-Ab-1/ GM-Tg-cang-T98913-Ab-2Anti-Canine G-CSF-R/CSF3R monoclonal antibodyCanine
GM-Tg-bovg-T98913-Ab-1/ GM-Tg-bovg-T98913-Ab-2Anti-Bovine G-CSF-R/CSF3R monoclonal antibodyBovine
GM-Tg-equg-T98913-Ab-1/ GM-Tg-equg-T98913-Ab-2Anti-Equine G-CSF-R/CSF3R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T98913-Ab-1/ GM-Tg-hg-T98913-Ab-2; GM-Tg-rg-T98913-Ab-1/ GM-Tg-rg-T98913-Ab-2;
GM-Tg-mg-T98913-Ab-1/ GM-Tg-mg-T98913-Ab-2; GM-Tg-cynog-T98913-Ab-1/ GM-Tg-cynog-T98913-Ab-2;
GM-Tg-felg-T98913-Ab-1/ GM-Tg-felg-T98913-Ab-2; GM-Tg-cang-T98913-Ab-1/ GM-Tg-cang-T98913-Ab-2;
GM-Tg-bovg-T98913-Ab-1/ GM-Tg-bovg-T98913-Ab-2; GM-Tg-equg-T98913-Ab-1/ GM-Tg-equg-T98913-Ab-2
Products NameAnti-G-CSF-R/CSF3R monoclonal antibody
Formatmab
Target NameG-CSF-R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-G-CSF-R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-818
    BiosimilarGMP-Bios-INN-812Pre-Made Efbemalenograstim Alfa Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7
    BiosimilarGMP-Bios-INN-852Pre-Made Filgrastim Biosimilar, Recombinant Protein targeting CSF3R: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7
    BiosimilarGMP-Bios-INN-748Pre-Made Balugrastim Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with ALB (albumin, human serum albumin, HSA): Recombinant therapeutic protein targeting CD114/GCSFR/SCN7
    BiosimilarGMP-Bios-ab-655Pre-Made Anumigilimab biosimilar, Whole mAb, Anti-CSF3R/G-CSF-R Antibody: Anti-CD114/GCSFR/SCN7 therapeutic antibody
    BiosimilarGMP-Bios-INN-951
    Target AntigenProducts DevelopingMulti-species CSF3R/ G-CSF-R/ CD114 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T98913
    Target NameG-CSF-R
    Gene ID1441,12986,298518,713485,607605,101089787,100069253
    Gene Symbol and SynonymsCD114,CSF3R,Csfgr,G-CSF-R,G-CSFR,GCSFR,SCN7
    Uniprot AccessionQ99062
    Uniprot Entry NameCSF3R_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000119535
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: G-CSF-R, gene name: CSF3R, also named as CD114, GCSFR, SCN7. The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.