Anti-THRB monoclonal antibody

Pre-made anti-THRB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to THRB/THRB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T98933-Ab-1/ GM-Tg-hg-T98933-Ab-2Anti-Human THRB monoclonal antibodyHuman
GM-Tg-rg-T98933-Ab-1/ GM-Tg-rg-T98933-Ab-2Anti-Rat THRB monoclonal antibodyRat
GM-Tg-mg-T98933-Ab-1/ GM-Tg-mg-T98933-Ab-2Anti-Mouse THRB monoclonal antibodyMouse
GM-Tg-cynog-T98933-Ab-1/ GM-Tg-cynog-T98933-Ab-2Anti-Cynomolgus/ Rhesus macaque THRB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T98933-Ab-1/ GM-Tg-felg-T98933-Ab-2Anti-Feline THRB monoclonal antibodyFeline
GM-Tg-cang-T98933-Ab-1/ GM-Tg-cang-T98933-Ab-2Anti-Canine THRB monoclonal antibodyCanine
GM-Tg-bovg-T98933-Ab-1/ GM-Tg-bovg-T98933-Ab-2Anti-Bovine THRB monoclonal antibodyBovine
GM-Tg-equg-T98933-Ab-1/ GM-Tg-equg-T98933-Ab-2Anti-Equine THRB monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T98933-Ab-1/ GM-Tg-hg-T98933-Ab-2; GM-Tg-rg-T98933-Ab-1/ GM-Tg-rg-T98933-Ab-2;
GM-Tg-mg-T98933-Ab-1/ GM-Tg-mg-T98933-Ab-2; GM-Tg-cynog-T98933-Ab-1/ GM-Tg-cynog-T98933-Ab-2;
GM-Tg-felg-T98933-Ab-1/ GM-Tg-felg-T98933-Ab-2; GM-Tg-cang-T98933-Ab-1/ GM-Tg-cang-T98933-Ab-2;
GM-Tg-bovg-T98933-Ab-1/ GM-Tg-bovg-T98933-Ab-2; GM-Tg-equg-T98933-Ab-1/ GM-Tg-equg-T98933-Ab-2
Products NameAnti-THRB monoclonal antibody
Formatmab
Target NameTHRB
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-THRB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T98933-Ag-1Recombinant multi-species THB/ THRB/ C-ERBA-2 protein
    ORF Viral VectorpGMLP000779human THRB Lentivirus plasmid
    ORF Viral VectorvGMLP000779human THRB Lentivirus particle


    Target information

    Target IDGM-T98933
    Target NameTHRB
    Gene ID7068,21834,24831,100429549,403599,101084821,788329,100051615
    Gene Symbol and SynonymsC-ERBA-2,C-ERBA-BETA,c-erbAbeta,ERBA2,GRTH,NR1A2,PRTH,RATT3REC,T3Rbeta,T3rec,T3R[b],THR,THR1,THRB,THRB1,THRB2,THRbeta,THRbeta1,Thrbeta2,TRb,TRbeta,TRbeta1
    Uniprot AccessionP10828,P18113
    Uniprot Entry NameTHB_HUMAN,THB_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000151090
    Target ClassificationNuclear Receptors, Tumor-associated antigen (TAA)

    The target: THRB, gene name: THRB, also named as C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR11, THRB2, THRB. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.